Flashcards in Amyotrophic lateral sclerosis (ALS/Lou Gehrig disease) Deck (12)
Drugs used for ALS - 3 drugs
Baclofen - MOA
Activate GABAb receptor and reduce motor neuron excitability
Which drug is used to reduce spasticity in ALS and MS?
Baclofen - adm
Oral, injectable, intrathecal infusion.
Baclofen - adverse effects
Dizziness, fatigue, weakness
Which drug may slow the loss of muscle strength in ALS?
Which drug may slow progression of disease and prolong life in ALS?
Gabapentin - adverse effects
Ataxia, dizziness, drowsiness, nystagmus, tremor
Gabapentin - interactions
Antacids decrease levels
Riluzole - MOA
Protect motor neurons from the neurotoxic effects of excitatory amino acids, and prevent anoxia-related death of cortical neurons. Unclear mechanism, maybe inhibition of voltage-gated sodium channels that mediate glutamate release
Riluzole - adverse effects
Asthenia, diarrhea, dizziness, drowsiness, increased hepatic enzyme levels, nausea, vomiting, paresthesias, vertigo