Amyotrophic lateral sclerosis (ALS/Lou Gehrig disease) Flashcards Preview

24 Neurodegenerative diseases > Amyotrophic lateral sclerosis (ALS/Lou Gehrig disease) > Flashcards

Flashcards in Amyotrophic lateral sclerosis (ALS/Lou Gehrig disease) Deck (12)
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1

Drugs used for ALS - 3 drugs

Baclofen
Gabapentin
Riluzole

2

Baclofen - MOA

Activate GABAb receptor and reduce motor neuron excitability

3

Which drug is used to reduce spasticity in ALS and MS?

Baclofen

4

Baclofen - adm

Oral, injectable, intrathecal infusion.

5

Baclofen - adverse effects

Dizziness, fatigue, weakness

6

Which drug may slow the loss of muscle strength in ALS?

Gabapentin

7

Which drug may slow progression of disease and prolong life in ALS?

Riluzole

8

Gabapentin - adverse effects

Ataxia, dizziness, drowsiness, nystagmus, tremor

9

Gabapentin - interactions

Antacids decrease levels

10

Riluzole - MOA

Protect motor neurons from the neurotoxic effects of excitatory amino acids, and prevent anoxia-related death of cortical neurons. Unclear mechanism, maybe inhibition of voltage-gated sodium channels that mediate glutamate release

11

Riluzole - adverse effects

Asthenia, diarrhea, dizziness, drowsiness, increased hepatic enzyme levels, nausea, vomiting, paresthesias, vertigo

12

Riluzole - interactions

Quinolones and theophylline can increase serum levels.
Omeprazole, rifampin and smoking can decrease serum levels.