Antispastic agents (muscle relaxants) Flashcards Preview

24 Neurodegenerative diseases > Antispastic agents (muscle relaxants) > Flashcards

Flashcards in Antispastic agents (muscle relaxants) Deck (11)
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1

Antispastic agents - 7 drugs

Baclofen
Tizanidine
Cyclobenzaprine, orphenadrine.
Carisoprodol
Dantrolene
Botox

2

Baclofen - indications

Severe spasticity (MS & ALS)

3

Tizanidine - MOA

Blocking nerve impulses through presynaptic inhibition of motor neurons. Decreases spasticity without reduction of muscle strength.

4

Tizanidine - indications

Spasticity of MS

5

Cyclobenzaprine, orphenadrine - MOA

Centrally mediated effects on catecholamine reuptake, antimuscarinic and antihistaminergic receptor actions

6

Cyclobenzaprine, orphenadrine - Indications

Short-term management of muscle spasms caused by acute painful, musculoskeletal conditions. (not effective in MS, ALS or cerebral palsy)

7

Carisoprodol - indications

Short-term treatment of muscle spasms caused by musculoskeletal conditions

8

Dantrolene - MOA

Blocks release of calcium ions from SR of muscle fibers. Direct muscle relaxation.

9

Dantrolene - indications

Malignant hyperthermia (life-saving) triggered by halogenated anesthetics. Neuroleptic malignant syndrome after high-potency neuroleptic. Spasticity from many disorders (stroke, paraplegia, cerebral palsy, MS).

10

Botox - MOA

Paralyses muscles by blocking release of acetylcholine on presynaptic side of the muscle end-plate junction

11

Botulinum toxin A - indications

Upper-limb spasticity after stroke. Cervical dystonia and other PD symptoms. Strabismus, blepharospasm (eyelid spasms), urinary incontinence after spinal cord injury (overreactive detrusor muscle)