Flashcards in Amino acids, peptides, and protein II LO Deck (14)
what are the 3 bonds that form the backbone of a polypeptide chain?
1. alpha carbon to carbonyl carbon within first amino acid
2. peptide bond between carbonyl carbon of 1st AA and amide nitrogen of 2nd
3. amid carbon of 2nd AA to alpha carbon of 2nd AA
what determines the function of the protein?
the amino acid sequence brahhhhh
what are 3 things that occur with amino acid sequence mutations?
1. misfolding or unstable proteins
2. truncated or extended proteins
3. proteins that no longer respond to regulation
(all of these changes can cause disease)
what is the function of a protease?
hydrolyze peptide bonds at specific amino acid sequences
what does hydrolysis of peptide bonds do?
causes proteins to be active, causes proteins to degrade but mostly just activation of proteins
what are the atoms that hydrogen bonds mostly form with?
H with N, O, F
what is the location of hydrogen bonds in alpha helices?
carbonyl oxygen of nth AA with amid nitrogen of n+4th AA
where do all of the side chains of an alpha helix face?
outward from the helix
what is the relationship of the 1st 8 residues in an alpha helix?
stacked on top of each other
how are beta sheets formed?
hydrogen bonds between 2 polypeptide chains
what are the 2 orientations of beta sheets?
parallel and anti-parallel
what is an example of a molecule made completely out of beta sheets?
what kind of screw does an alpha helix form?
right handed screw