Crohn's disease Flashcards Preview

M2M Biochemistry and molecular biology > Crohn's disease > Flashcards

Flashcards in Crohn's disease Deck (16):
1

what are the 2 causes of idiopathic inflammatory bowel disease (IBD)?

Crohn's disease and ulcerative colitis

2

when is the peak onset of IBD?

15-30 years old

3

what increases risk of crohn's disease?

smoking

4

which disease always affects the illeum and colon?

Crohn's disease

5

what disease always includes the rectum and almost always the colon?

`ulcerative colitis

6

what disease is continuous within the colon?

ulcerative colitis

7

what disease is discontinuous in the GI tract?

Crohn's disease

8

which disease is hematochezia common?

ulcerative colitis

9

which disease rarely has intestinal granulomas, strictures, and fistulas?

ulcerative colitis

10

which disease includes the upper GI tract?

Crohn's

11

What type of inflammation is present in Crohn's disease?

transmural

12

what type of inflammation is present in ulcerative colitis?

mucosal

13

what percentage of patients show extra-intestinal manifestations?

25%

14

what is the etiology of IBD?

inappropriate inflammatory response to intestinal microbes in a genetically susceptible host

15

what are the genetic factors related to IBD?

1. nucleotide oligomerization domain 2 (NOD2)
2. interleukin-23-type 17 helper T-cell (Th17) pathway
3. autophagy genes

16

what are 4 causes of rising prevalence of IBD?

1. changes in diet
2. antibiotic use
3. altered intestinal colonization
4. tobacco