Anaphylactic shock Flashcards
(27 cards)
Where do T lymphocytes mature
Thymus
Where do B lymphocytes mature
Bone marrow
Do T lymphocytes or B lymphocytes use antibodies?
Just B
What cells are involved in innate immunity
- Neutrophils
- Monocytes
- Eosinophils
- Mast cells
- Basophils
Functions of the antibody IgG
Blocks pathogen binding
Activates complement
Opsonine antigen for phagocytosis
Functions of the antibody IgM
Blocks pathogen binding
Activates complement cascade
Functions of the antibody IgA
Blocks pathogen binding
Where is IgA found
Tears
Digestive juices
Functions of IgE
Activates mast cells
4 ways that mast cell activation can occur
Crosslinking of surface IgE
Via complement (C3a and C5a)
Via nerves
Direct pathogen contact
What happens once mast cells are activated
Mediators are released
What mediators are released by mast cells
Histamine
Leukotrienes
Prostaglandins
What is the action of histamine
Increases permeability of post capillary venules, arteriole vasodilation, smooth muscle constriction
What is the action of leukotrienes
Increases permeabilty of post capillary venules, chemotaxis
What is the action of prostaglandins
Arteriolar dilation
Define atrophy
Inherited predisposition to make IgE to common environemental antigens
What are some examples of local manifestations of type 1 sensitivity
eczema allergic rhinitis asthma uticeria angioderma
What are some examples of systemic type 1 sensitivity
Anaphylactic shock
What is blood pressure like in anaphylactic shock and why
Low due to fluid leaking to interstitial dilation in great veins
Is there bronchoconstriction or bronchodilation in anaphylactic shock
Bronchoconstriction
Name some skin symptoms of anaphylactic shock
Utircaria
Red itchy eyes
Erythema
Where in the body does angioedema occur
Face, lips, hands, feets, pharynx and larynx
What is first treatment for anaphylaxis
Adrenaline
How much adrenaline is administered IM
500mg in 0.5mls
