Anaphylaxis

Question 1

Treatments for Hereditary/Acquire Angioedema

Answer 1

1. C1 inhibitor concentrate
2. Ecallantide (kallikrein inhibitor)
3. Icatabant (bradykinin receptor antagonist)

Question 2

Deficiency Seen in Heriditary Angioedema (HAE/AAE)

Answer 2

C1 inhibitor

Question 3

Anaphylaxis results from overstimulation of which vasoactive substrate

Answer 3

IgE mast-cell mediated substances: histamines, leukotrienes, PAF, prostaglandins

Question 4

Anaphylaxis is Type ___ Hypersensitivity

Answer 4

I

Question 5

Anaphylaxis clinical features

Answer 5

1. Capillary Leak (hypotension)
2. Mucosal edema
3. Smooth muscle contraction

Question 6

Anaphylactic Grades

Answer 6

I: urticaria, angioedema, flushing
II: Resp, CV, +/- GI
III: “SHOCK”: Hypotension, hypoxemia, LOC
IV: Cardiac arrest, apnea

Question 7

Marker for severity of anaphylaxis

Answer 7

↑ circulatory PAF

↑ trypase (for venom allergen)

Question 8

Anaphylactic Tx

Answer 8

Epinephrine

2nd line: antihistamines, bronchodilators, corticosteroids, vasopressure, IV fluids