1. Genetics - polygenetics (mutations for early complement factors C1q, C2, and C4 and hypomethylation of DNA) 2. Hormonal factors (e.g., early menache and estrogen treatment) 3. Environmental factors (light, sulfa-drugs, EBV - molecular mimicry, smoking, silica)

Systemic Lupus Erythema (SLE) Flashcards by Jian Chu

Epidemiology (Age and gender)

F > M, 7-15:1
Blacks > Latinas > Asians > Caucasians
Peak ages (30-50)

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Risk Factors

Genetics - polygenetics (mutations for early complement factors C1q, C2, and C4 and hypomethylation of DNA)
Hormonal factors (e.g., early menache and estrogen treatment)
Environmental factors (light, sulfa-drugs, EBV - molecular mimicry, smoking, silica)

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Define SOAP BRAIN MD

Serositis
Oral ulceration
Arthritis
Pleuritic pain or Photosensitivity

Blood (anemia)
Renal
ANA
Immunologic
Neurological

Malar rash
Discoid Lupus

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Systemic Lupus Erythema (SLE) Flashcards

(3 cards)