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Flashcards in Anemias/Leukemias Deck (79)
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61

What is the most common aggressive form of NHL?

Diffuse large B-cell lymphoma

62

Diffuse large B-cell lymphoma

Lymphocyte tissue is infiltrated with large lymphoid cells that have irregular outlines and prominent nucleoli.

  • commonly spread into parenchyma of major organs
  • Tx: CHEMO!!!! 75% remission

63

True or False:

Burkitt's lymphoma can be cured

TRUE

 

Responds to CHEMO

64

Burkitt's lymphoma

Highly malignant, with small B cells that divide rapidly

  • cells prone to apoptosis, "starry sky"
  • originates in BM or lymph nodes
  • endemic in children with EBV
  • common in subsaharan Africa

65

How does Burkitt's lymphoma present outside of endemic areas?

abdominal masses

66

What does in mean that Hodgkin’s lymphoma is BIMODAL?

It peaks at 25 yrs and also at 55 yrs. 

67

What is a Reed Sternberg cell?

Binucleated and multinucleated.

68

Classical Hodgkin's Lymphoma Divisions

  1. Lymphocyte-rich classical 
  2. Nodular sclerosis 
  3. Mixed-cellularity 
  4. Lymphocyte-depleted 

69

Non-classical HL

Nodular lymphocyte predominant HL

"popcorn cell"

70

Clinical features of HL

  1. lymph node enlargement
    - neck nodes
    - mediastinal
    - central nodes
     
  2. High rate of CURE with CHEMO!

71

Involvement of single node or group of nodes

Stage 1

HL

72

Involvement of 2 or more sites of same side of diaphragm

Stage 2

HL

73

Disease on both sides of diaphragm; may include spleen or localized extranodal disease

Stage 3

HL

74

Widespread extralymphatic involvement (liver, bone marrow, lung, skin)

Stage 4

HL

75

What is multiple myeloma?

Malignant disease of plasma cells

 

76

With what disease do you find Bence Jones proteins in the urine?

Multiple Myeloma

77

What is the most common cause of death in multiple myeloma?

kidney failure

78

Which disease process do you find "punched out" lesions in radiographs of the skull, ribs, and vertebrae?

Multiple myeloma

79

Multiple Myeloma

Begins with single malignant plasma cell.

  • secrete all the same form of Ig! = monoclonal "spike" on electrophoresis
  • Old age
  • punched out holes in blood forming bones
  • hypercalcemia
  • anemia, leukopenia, thrombocytopenia
  • CHEMO is INEFFECTIVE