What is the most common aggressive form of NHL?
Diffuse large B-cell lymphoma
Diffuse large B-cell lymphoma
Lymphocyte tissue is infiltrated with large lymphoid cells that have irregular outlines and prominent nucleoli.
- commonly spread into parenchyma of major organs
- Tx: CHEMO!!!! 75% remission
True or False:
Burkitt's lymphoma can be cured
TRUE
Responds to CHEMO
Burkitt's lymphoma
Highly malignant, with small B cells that divide rapidly
- cells prone to apoptosis, "starry sky"
- originates in BM or lymph nodes
- endemic in children with EBV
- common in subsaharan Africa
How does Burkitt's lymphoma present outside of endemic areas?
abdominal masses
What does in mean that Hodgkin’s lymphoma is BIMODAL?
It peaks at 25 yrs and also at 55 yrs.
What is a Reed Sternberg cell?
Binucleated and multinucleated.
Classical Hodgkin's Lymphoma Divisions
- Lymphocyte-rich classical
- Nodular sclerosis
- Mixed-cellularity
- Lymphocyte-depleted
Non-classical HL
Nodular lymphocyte predominant HL
"popcorn cell"
Clinical features of HL
- lymph node enlargement
- neck nodes
- mediastinal
- central nodes
- High rate of CURE with CHEMO!
- neck nodes
- mediastinal
- central nodes
Involvement of single node or group of nodes
Stage 1
HL
Involvement of 2 or more sites of same side of diaphragm
Stage 2
HL
Disease on both sides of diaphragm; may include spleen or localized extranodal disease
Stage 3
HL
Widespread extralymphatic involvement (liver, bone marrow, lung, skin)
Stage 4
HL
What is multiple myeloma?
Malignant disease of plasma cells
With what disease do you find Bence Jones proteins in the urine?
Multiple Myeloma
What is the most common cause of death in multiple myeloma?
kidney failure
Which disease process do you find "punched out" lesions in radiographs of the skull, ribs, and vertebrae?
Multiple myeloma
Multiple Myeloma
Begins with single malignant plasma cell.
- secrete all the same form of Ig! = monoclonal "spike" on electrophoresis
- Old age
- punched out holes in blood forming bones
- hypercalcemia
- anemia, leukopenia, thrombocytopenia
- CHEMO is INEFFECTIVE
