Angina Drugs Flashcards
1
Q
Name the two nitrate drugs. (2)
A
- Glyceryl trinitrate
- Isosorbide dinitrate
2
Q
What is special about Glyceryl trinitrate?
A
- It is a pro-drug.
- Ineffective until, metabolised in the liver.
3
Q
What is the risk when using Isosorbide dinitrate?
A
Tolerance can be developed.
4
Q
What are the effects of Nicorandil?
A
- Vasodilation of blood vessels
- A pro-drug
5
Q
How does Nicroandil act?
A
By activating potassium channels.
6
Q
How does Nifedipine act?
A
By blocking calcium channels.
7
Q
What are the effects of Nifedipine?
A
- Dilating arterioles, which reduces cardiac afterload.
- Reducing cardiac work and oxygen needed.
- More potent on vascular smooth muscle than the heart
8
Q
How does Verapamil act?
A
By blocking calcium channels.
9
Q
What are the effects of Verapamil?
A
- Reduces heart rate and cardiac output.
- Reducing cardiac work and oxygen needed.
- More potent on the heart.
10
Q
How does Digoxin act?
A
By increasing the strength of cardiac muscle contraction.
11
Q
What are the effects of Digoxin?
A
- Increase vagus nerve activity
- Slowing SA node firing rate and ventricular rate.
