Anticoagulants and Atherosclerosis Drugs Flashcards
What does Heparin inhibit?
- Thrombin
- Factor X
- Factor IX
What results from the actions of Heparin?
- Fibrinogen can’t be converted to fribrin.
- Preventing formation of clots.
- Increases strength of ATIII binding. (Thrombin inhibitor).
What are the risks of using Heparin?
Risks of haemorrhage.
What does Warfarin inhibit?
Competivitely inhibits Vitamin K reductase.
What results from the actions of Warfarin?
- Vitamin K can’t be recycled.
- Various clotting factors can’t be made.
How does Aspirin act on the body?
- Irreversibly inhibits platelet COX enzyme.
What effects does Aspirin have?
- Reduces TxA2 synthesis
- Reducing platelet aggregation, until new platelets are made.
How do Statins act on the body?
- Competitvely inhibit HMG-CoA reductase
What effects do Statins have?
- Lowers the production of cholesterol
- Leading to more LDL receptors, which increases removal of LDL from plasma.
What does Ezetimibe inhibit?
A specific cholesterol transporter in the gut.
What effects does Ezetimibe have?
Inhibits intestinal cholesterol absorption.
What is Colestyramine?
An anion exchange resin
What effects does Colestyramine have?
- Stops bile acids from being reabsorbed by binding to them.
- Increases conversion of new cholesterol into bile acids.
- Increases uptake of LDL by the liver.
Which receptors are Fibrates agonists for?
A nuclear hormone receptor called PPAR-alpha.
How do Fibrates work?
Alter transcription of some genes involved in lipid metabolism.
