Animal Models of Addiction

Question 1

3 Lab models to study neural basis of drug addiction?

Answer 1

Drug self-administration paradigm- rat presses lever to receive drug into brain or circulation

Conditioned place preference paradigm- tests rats preference for place in which it previously experienced drug effects

Intracranial Self Stimulation

Question 2

what do Fixed Ratio Schedules measure ?

Answer 2

typical measure rate or number of responses (or infusions) inverted U curve

graph drops due to satiety, adverse affects, loss of reward and incapacity

Question 3

what are Progressive ratio schedules?

Answer 3

how much will the animal work for the reward if the difficulty of achieving it is increased.

defined by breakpoint

Question 4

GABAb anatgonist blocked establishment of what in rats administered nicotine ?

Answer 4

establishment of conditioned place preference

Question 5

siegels theory predicts that

Answer 5

drug environments predict a compensatory response

Compensatory responses are aversive. counteract drug state.
Accidental overdose in novel environment

Question 6

how do drugs of abuse affect the ICSS reward thersold

Answer 6

they lower it

Question 7

cheapdate mutant flies have a heightened sensitivity to ?

Answer 7

ethanol

Question 8

measure of drug reward tests?

Answer 8

Goal is to determine abuse potential of different drugs and to study mechanisms by which drugs produce rewarding effects and dependence and thus lead to treatments for dependence

Measure effects on withdrawal symptoms
Self-administration paradigms
Conditional place preference

Question 9

Effects on withdrawal steps ?

Answer 9

Steps:
Produce physical dependence with prototypical drug (e.g., morphine; nicotine)
Withdraw and give unknown
If block withdrawal symptoms will may be useful as anti-addictive agent
*May have abuse potential