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KMK - Ocular Disease > Anterior Uveitis > Flashcards

Anterior Uveitis Flashcards

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1
Q

Uveitis typically occurs in what age range?

A

Young adults (2nd-4th decade)

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2
Q

Uveitis generally only occurs in adults over 70 if associated with what 2 things?

A

Toxoplasmosis

Herpes zoster

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3
Q

Uveitis occurs secondary to what?

A

Breakdown of the blood-aqueous barrier

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4
Q

What are the 3 locations of the blood aqueous barrier?

A
  1. Non-pigmented ciliary epithelium (NPCE)
  2. Iris vessels
  3. Schlemm’s canal
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5
Q

50% of patients with acute anterior uveitis are positive for what gene?

A

HLA-B27

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6
Q

What conditions are associated with the HLA-B27 gene?

A 
(CRAP)
Crohn's
Reactive arthritis
Ankylosing spondylitis
Psoriatic arthritis
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7
Q

What are the two types of anterior uveitis?

A

Acute, non-granulomatous

Chronic, granulomatous (bilateral)

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8
Q

What is the most common systemic cause of anterior, acute, non-granulomatous uveitis?

A

Ankylosing spondylitis

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9
Q

Chronic, bilateral, granulomatous uveitis is commonly associated with what 3 conditions?

A

Sarcoid
TB
Syphilis

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10
Q

Keratic precipitates are commonly found in which type of anterior uveitis?

A

Chronic, granulomatous

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11
Q

Rank the types of uveitis from most common to least common.

A
  1. Anterior uveitis (iritis, iridocyclitis)
  2. Posterior or panuveitis
  3. Intermediate (pars planitis)
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12
Q

Stellate KPs are commonly seen in what two conditions?

A

Fuch’s heterochromic iritis

Herpes

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13
Q

What are the common symptoms of uveitis?

A 
Pain
Redness
Photophobia
Lacrimation
Mildly decreased VA (especially with CME)
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14
Q

Which nerves are causing the pain in anterior uveitis?

A

Anterior ciliary nerves

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15
Q

What are the common signs of anterior uveitis?

A 
WBCs in the anterior chamber
Flare
Hypopyon
Circumlimbal injection
IOP elevation (early stages)
KPs
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16
Q

IOP may be decrease during which stages of uveitis, and in which eye?

A

Early stages

Affected eye

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17
Q

What are the main threats to vision in uveitis?

A

PAS
PS
CME
Cataract formation

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18
Q

What type of cataract is common in anterior uveitis?

A

PSC

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19
Q

Why might IOP increase in the affected eye in the later stages of uveitis?

A

PAS or PS formation

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20
Q

Fine KPs are characteristic of (granulomatous/non-granulomatous) etiology.

A

Non-granulomatous

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21
Q

Granulomatous etiology of uveitis is more common with what cause?

A

Infection (TB, syphilis)

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22
Q

What iris nodules may be found in granulomatous uveitis?

A

Koeppe

Busacca

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23
Q

In what layer of the iris are Koeppe and Busacca nodules found?

24
Q

What make up mutton fat KPs?

25
What are Koeppe nodules?
Collections of WBCs on the pupillary margin
26
What are Busacca nodules?
Collections of WBCs of any part of the iris stroma that is not the pupillary margin
27
Busacca nodules are pathognomonic what what etiology of uveitis?
Granulomatous
28
Koeppe nodules are associated with which etiology of uveitis?
Both granulomatous and non-granulomatous
29
What are the most common corneal findings in anterior uveitis?
KPs
30
Acute, non-granulomatous, anterior uveitis is commonly associated with what 7 diseases?
``` IBS Reactive arthritis Ankylosing spondylitis Psoriatic arthritis Behcet's disease Lyme disease Glaucomatocyclitis Crisis (Posner-Schlossman) ```
31
What characterizes reactive arthritis?
Young males with urethritis, polyarthritis, and conjunctivitis (with iritis)
32
What characterizes psoriatic arthritis?
Peripheral, small joint pain | Psoriatic lesions on the knees, elbows, and scalp
33
What characterizes Behcet's disease?
Acute, recurrent hypopyon iritis | Mouth and genital ulcers
34
Chronic, granulomatous, anterior uveitis may be associated with what major 4 conditions?
Sarcoidosis TB Herpes Simplex/Zoster Syphilis
35
Sarcoidosis associated uveitis is typically (unilateral/bilateral).
Bilateral
36
What type of uveitis is associated with sarcoidosis?
May be either posterior or panuveitis
37
What abnormal findings are common in sarcoidosis?
Abnormal chest x-ray | Increased ACE levels
38
What are common signs/symptoms of TB?
Positive PPD Abnormal chest x-ray Night sweats
39
What type of uveitis is commonly associated with TB?
Posterior | Panuveitis
40
Herpes simplex/zoster associated uveitis is commonly associated with increased what of the involved eye?
IOP
41
What type of KPs may be present in herpes associated uveitis?
Stellate KPs
42
What are common ocular findings of herpes associated uveitis?
KPs Corneal edema Epithelial defects
43
What 3 things characterize syphilis?
Maculopapular rash of palms and/or soles Positive VDRL or RPR Positive FTA-ABS or MHA-TP
44
Syphilis associated uveitis may have what associated corneal finding?
Interstitial keratitis
45
What is interstitial keratitis?
Stromal inflammation without primary involvement of the epithelium or endothelium
46
What characterizes interstitial keratitis?
Acute stromal inflammatory edema and neo
47
What are the most common causes of interstitial keratitis?
Congenital syphilis TB Herpes simplex
48
What is the triad of congenital syphilis?
Hutchinson's teeth (small, spaced teeth) Deafness Interstitial keratitis
49
Chronic, non-granulomatous, anterior uveitis may be associated with what two main conditions?
Juvenile idiopathic arthritis (JRA) | Fuchs' heterochromic iridocyclitis
50
What three drugs/classes can cause anterior uveitis?
Rifabutin Systemic sulfonamides Cidofovir
51
What is the most common knowns cause of uveitis in kids?
Juvenile idiopathic arthritis
52
Which gender typically gets JRA (or JIA)?
Young girls
53
What is the classic presentation of JRA (JIA)?
Bilateral uveitis in young girls
54
Patients with JRA (JIA) typically have what RF and ANA findings?
Negative RF | Positive ANA
55
Fuchs' heterochromic iridocyclitis occurs most frequently in patients with what color eyes?
Blue
56
What characterizes Fuchs' heterochromic iridocyclitis?
Unilateral, mild uveitis Fine stellate KPs Angle neo Iris heterochromia
57
Pars planitis is associated with what systemic conditions?
None - trick question!

KMK - Ocular Disease (20 decks)

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