Anti Cancer drugs

Question 1

Reverse

Pyrimidine antimetabolite that inhibits thymidylate synthetase

Answer 1

5-FU mechanism of action

Question 2

Reverse

Iron-chelating agent preventing the formation of free radicals

Answer 2

Dexrazoxane mechanism of action

Question 3

Reverse

• Antimetabolite
• Inhibits DHF reductase (S phase)

Answer 3

Methotrexate mechanism of action

Question 4

Reverse

• Increase lymphocyte differentitaion and Increase NKs
• Use in RCC and Metastatic melanoma

Answer 4

IL-2 used for

Question 5

Reverse

1. Alkylating agents
2. Antitumor antibiotics
3. Nitrosoureas

Answer 5

Non-cell cycle specific drugs

Question 6

Reverse

Compleses with Fe and O₂ causes DNA strand scission

Answer 6

Bleomycin mechanism of action

Question 7

Reverse

1. Pneumonitis
2. Pulmonary fibrosis

Answer 7

Bleomycin adverse affects

Question 8

Reverse

Bleomycin

Answer 8

G₂ Specific drugs

Question 9

Reverse

• Decrease microtubular polymerization
• Spindle poisons

Answer 9

Vinblastine/Vincristine mechanism of action

Question 10

Reverse

• Intercalator
• Forms free radicals
• Inhibits Topoisomerase

Answer 10

Doxorubicin mechanism of action

Question 11

Reverse

Delayed CHF (give dexrazoxane)

Answer 11

Doxorubicin adverse affects

Question 12

Reverse

1. BMS
2. Give Leucovorin for Folinic acid rescue

Answer 12

Methotrexate adverse affects

Question 13

Reverse

Anemias

Answer 13

Erythropoietin used for

Question 14

Reverse

Thrombocytopenia

Answer 14

Thrombopoietin used for

Question 15

Reverse

• Increase granulocytes
• Marrow recovery

Answer 15

Filgrastim (G-CSF) used for

Question 16

Reverse

• Alkylating agent
• Cross-links DNA strands

Answer 16

Cisplatin mechanism of action

Question 17

Reverse

-mustine

Answer 17

Nitrosoureas

Question 18

Reverse

• Alkylating agent
• Attacks guanine N7 and produces a dysfunctional DNA

Answer 18

Cyclophosphamide mechanism of action

Question 19

Reverse

1. Vinblastine: Blocks tubular polymerization
2. Vincristine: Blocks tubular polymerization
3. Paclitaxel: Blocks depolymerization of microtubules

Answer 19

M phase specific drugs

Question 20

Reverse

1. Doxorubicin
2. Daunorubicin

Answer 20

Antitumor antibiotics

Question 21

Reverse

• Increase granulocytes and macrophages
• Marrow recovery

Answer 21

Sargramostim (GM-CSF) used for

Question 22

Reverse

1. Increase platelet formation
2. Used in Thrombocytopenia

Answer 22

IL-11 used for

Question 23

Reverse

1. Cytarabine
2. 6-mercaptopurine
3. 6-thioguanine
4. 5-FU
5. Methotrexate
6. Hydroxyurea

Answer 23

S phase specific drugs

Question 24

Reverse

Purine antimetabolite that bioactivated by HGPR transferase

Answer 24

6-Mercaptopurine mechanism of action

Question 25

# Reverse 1. Cyclophosphamide 2. Cislplatin 3. Procarbazine

Answer 25

Alkylating agents

Question 26

# Reverse Neurotoxicity

Answer 26

Vinblastine/Vincristine adverse affects

Question 27

# Reverse Hemorrhagic cystits (**give MESNA**)

Answer 27

Cyclophosphamide adverse affects

Question 28

# Reverse 1. Nephrotoxicity (give **Amifostine**) 2. Neurotoxicity (deafness)

Answer 28

Cisplatin adverse affects