Pharmacokinetics

Question 1

1 X t1/2 =

Answer 1

50%

Question 2

3.3 X t1/2 =

Answer 2

90%

Question 3

4 to 5 X t1/2 =

Answer 3

95%

Question 4

Basic WA drugs

Answer 4

1. Asprin
2. Penicllin
3. Cephalosporin
4. Diuretics

Question 5

Basic WB drugs

Answer 5

1. Morphine
2. Local Anesthetics
3. Amphetamines
4. PCP

Question 6

Bioavailability (f) =

Answer 6

AUC_[Oral] / AUG_[IV]

Question 7

Blood volume VD

Answer 7

5L

Question 8

CYP450 - 1A2 Inhibitors

Answer 8

1. Quinolones
2. Macrolides

Question 9

CYP450 - 1A2 Substrate

Answer 9

1. Theophylline
2. Acetaminophen

Question 10

CYP450 - 2C9 Substrate

Answer 10

1. Phenytoin
2. Warfarin

Question 11

CYP450 - 2D6 inhibitors

Answer 11

1. Haloperidol
2. Quinidine

Question 12

CYP450 - 2D6 Substrate

Answer 12

CVS and CNS drugs

Question 13

CYP450 General inducers

CRAP GPS

Answer 13

• Carbamazapine
• Rifampin
• Alcohol (Chronic)
• Phenytoin
• Griseofluvin
• Phenobarbs
• Sulphonylureas

Question 14

CYP450 General Inhibitors

SICKFACES.COM Group

Answer 14

1. Sodium Valproate
2. Isoniazid
3. Cimetidine
4. Ketoconazole
5. Flucoconazole
6. Alcohol (bindge)
7. Chloremphemicol
8. Erythromycin
9. Sulfonamide
10. Ciprofloxacin
11. Omeprazole
12. Metronidazole
13. Grape fruit

Question 15

Drugs that undergo first-pass metabolism

Answer 15

1. Lidocaine
2. Nitroglycerin

Question 16

Drugs with Zero-order elimination

Answer 16

1. Ethanol
2. Phenytoin
3. Salicylate

Question 17

ECF volume VD

Answer 17

• 12-14L
• 16%
• Mannitol

Question 18

Extraction rate =

Answer 18

C_liver / Q

Q: Hepatic blood flow

Question 19

First Order of Elimination

Answer 19

• Constant FRACTION of the drug is eliminated per unit time
• t1/2 is CONSTANT
• Follows and exponential decay versus time
• Rate if elimination is Directly Proportional to plasma level

Question 20

Infusion rate (k₀) =

Answer 20

Cl X C^ss

Question 21

Loading Dose (LD) =

Answer 21

(VD X [Plasma]) / f

Question 22

Maintenance dose (MD) =

Answer 22

(Cl X C^ss X Γ) / f

Question 23

pH-pKa = -2 WB

Answer 23

1% nonionized

Question 24

pH-pKa= -2 for WA

Answer 24

99% nonionized

Question 25

Phase 1 Biotransformation

Answer 25

* Oxidation, reduction, or hydrolysis * Involves Cytochrome P40 found in **Smooth Endoplastic Reticulum**

Question 26

Phase 2 Biotransformation

Answer 26

Conjugation (attaching something to drug) with endogenous compounds via the activity of transferases * Glucuronidation * Acetylation * Glutathione Conjugation

Question 27

Plasma volume VD

Answer 27

* 3L * 4% * Heparin

Question 28

Systemic Bioavailability (F) =

Answer 28

f X (1-ER)

Question 29

t_1/2 =

Answer 29

.7 X (VD/Cl)

Question 30

TBW volume VD

Answer 30

* 40-42L * Ethanol

Question 31

Tissue Conc. VD

Answer 31

* Over 49L * Chloroquine

Question 32

Urine acidifier

Answer 32

1. NH₄Cl 2. Vit C 3. Cranberry Juice

Question 33

Urine Alkalinizer

Answer 33

1. NaHCO₃ 2. Acetazolamide

Question 34

Volume of Distribution (VD) =

Answer 34

Dose / C⁰ C⁰: [Plasma] at zero time

Question 35

Zero Order Elimination rate

Answer 35

* A Constant **AMOUNT** of drug is eleminated per unit time * Rate is **INDEPENDENT** of plasma concentration * Have **NO FIXED t1/2**