Drugs for Blood Disorders Flashcards
(28 cards)
Heparin mechanism of action
Catalyzes the binding of Antithrombin 3 (a serine protease inhibitor) resulting in their raped inactivation
What do you monitor for Heparin
PTT
What do you counteract Heparin in when there is Toxicity?
Protamine sulfate
What is Heparin used for
Rapid anticoagulation for thromboses, emboli, unstable angina, DIC
Heparin adverse affects
- Bleeding
- Osteoporosis
- HIT
- HS
Warfarin mechanism of action
Decrease hepatic synthesis of Vit K dependent factors (1972)
What do you monitor in Warfarn
PT and INR
Warfarin adverse affects
- Bleeding
- Skin necrosis (low Protein C)
- Drug interactions
- Teratogenic (Bone dysmorphogenesis)
Enoxaparin is
LMW Heparin that has a longer t-1/2 and less HIT
Protein C deficiency
Can be induced with Warfarin, so maintain Heparin until warfarin kicks in
Argatroban mechanism of action
Directly inhibit thrombin and do not require antithrombin 3
WHen do you use Argatroban
In HIT
Dabigatran mechanism of action
Directly inhibits thrombin and do not require antithrombin 3
Advantage of Dabigatran
Oral anticoagulant that does not need monitoring
Bivalirudin mechanism of action
Directly inhibit thrombin and does not require antithrombin 3
Rivaroxaban (-XABAN) mechanism of action
Directly inhibits factor 10a
Streptokinase mechanism of action
Acts on both bound and free plasminogen causing a depletion of circulating plasminogen and factor 5 and factor 8
Alteplace (tPA) mechanism of action
Clot specific, acting mainly on fibrin-bound plasminogen
Factors that activate platelets
- TXA2
- ADP
- Collagen
- 5HT
- Thrombin
Asprin role in antiplatelet
Cox inhibitor in platelets that decrease activation
Clopidogrel mechanism of action
Blocks ADP receptors on platelets decreasing activation
Prasugrel mechanism of action
Block ADP receptors on platelets
Ticagrelor mechanism of action
Block ADP receptors on platelets decreasing activation
Ticlopidine mechanism of action
Block ADP receptors on platelets decreasing activation
