Anti-coagulants

Question 1

Low dose ASA

Answer 1

selective for COX1, preserves PGI2

Question 2

ASA low dose effect

Answer 2

inhibits platelet aggregation

Question 3

ASA mid dose effect

Answer 3

Antipyretic, analgesic

Question 4

ASA high dose effect

Answer 4

Anti-inflammatory

Question 5

salicylism (toxicity)

Answer 5

CNS effects: confusion, tinnitus, dizziness, metabolic: respiratory ALKALOSIS, metabolic ACIDOSIS, renal

Question 6

If use warfarin + NSAID risk

Answer 6

BLEEDING!

Question 7

MOA: ADP receptor inhibitor

Answer 7

Clopidogrel/Plavix

Question 8

MOA: More selective in reducing CV w/ ATHEROSCLEROSIS

Answer 8

Clopidogrel/Plavix

Question 9

MOA: Blocks P2Y1/P2Y12

Answer 9

Clopidogrel/Plavix

Question 10

MOA: GPIIb/IIIa receptor

Answer 10

Abciximab

Question 11

-parin MOA

Answer 11

activation of antithrombin III

Question 12

Heparin form complexes w/

Answer 12

Factors: IIa, IXa, Xa

Question 13

Zero order kinetic

Answer 13

Heparin

Question 14

Inhibits X from activating prothrombin > thrombin

Answer 14

Enoxaparin

Question 15

Initial Tx of PE/PVT

Answer 15

-parins

Question 16

Use Heparin (HMWT) for pts

Answer 16

over 300 lbs

Question 17

SE: THROMBOCYTOPENIA, OSTEOPOROSIS, prolonged bleeding

Answer 17

-Parins

Question 18

MOA: vitamin K antagonist

Answer 18

Warfarin

Question 19

Warfarin forms complexes w/

Answer 19

II, VII, IX, V

Question 20

Slow onset of action

Answer 20

Warfarin

Question 21

PROPHYLAXIS of PE/DVT

Answer 21

Warfarin

Question 22

Warfarin CI:

Answer 22

Protein C deficiency
Preggo!
CYP3A4 drugs:
Barbs
Rifampin!

Question 23

Direct thrombin inhibitor

Answer 23

Dabigatran, -irudins

Question 24

Prevent stroke and blood clots in pts w/ abnormal heart rhythms

Answer 24

Dalbigatran/-irudin family!

Question 25

Dabigatran antidote

Answer 25

idarucizumab

Question 26

Direct Factor Xa inhibitors

Answer 26

-XA-ban! suffix

Question 27

Reduce stroke in patients w/ A-fib, tx DVT/PE after parenteral anticoagulant

Answer 27

-Xabans family!

Question 28

Xabans interactions

Answer 28

CYP3A4

Question 29

rapid lysis of thrombi

Answer 29

-plase suffix or Urokinase

Question 30

t-PA derrivatives

Answer 30

-plase, urokinase

Question 31

coronary artery thrombosis (MI)

Answer 31

-plase, urokinase drugs

Question 32

fribronolytic inhibitor

Answer 32

aminocaproic acid

Question 33

competitively inhibits plasminogen activation

Answer 33

aminocaproic acid

Question 34

CARBOXYLATES II, VII, IX, X

Answer 34

Vitamin K1

Question 35

Vitamin K1 AKA

Answer 35

phytonadione

Question 36

Vit K deficiency or excess warfarin

Answer 36

Vitamin K1

Question 37

Heparin Neutralizer

Answer 37

Protamin sulfate

Question 38

Antithrombin III acts on

Answer 38

IXa, Xa, IIa

Question 39

Villa

Answer 39

IX > IXa, X > Xa

Question 40

recurrent MI, thromboembolic events after MI

Answer 40

Warfarin

Question 41

In protein C deficiency, start warfarin w/

Answer 41

heparin first!

Question 42

Heparin antidote

Answer 42

Protamine

Question 43

SEVERE dvt tx

Answer 43

Fibrinolytics

Question 44

ascending thrombophlebitis of iliofemoral vein SEVERE LE EDEMA

Answer 44

fibrinolytics

Question 45

Primary Hemostasis

Answer 45

Oprelvekin/IL-11

Question 46

Secondary Hemostasis

Answer 46

replace vWD; -plase; IXa/X monoclonal ABs, fibronolytic inhibitors, Vit K1

Question 47

Formoterol, Salmeterol risk

Answer 47

Black box if not used w/ Steroids!

Question 48

-terol

Answer 48

target B2 receptors > bronchodilation!

Question 49

Albuterol, Levalbuterol

Answer 49

SABA

Question 50

Formoterol

Answer 50

LABA

Question 51

Salmeterol

Answer 51

LABA

Question 52

Olodaterol

Answer 52

ULABA

Question 53

Vilanterol

Answer 53

ULABA

Question 54

COPD use

Answer 54

ULABA

Question 55

SE: dysphonia, hoarseness, oropharyngeal candidiasis

Answer 55

Inhalant corticosteroids

Question 56

SEVERE ACUTE or SEVERE CHRONIC

Answer 56

prednisone, methylprednisone use 5 day or tapered dose

Question 57

SE: pituitary adrenal suppression

Answer 57

-prednisone

Question 58

Block ACh at M3 receptor

Answer 58

-tropium

Question 59

additive effects, used as adjunct to B2 agonists and steroids

Answer 59

muscarinic antagonists/-tropiums

Question 60

inhibits 5-lipoxygenase

Answer 60

Leukotriene Sx Inhibitor/Zileuton

Question 61

Leukotriene Antagonists

Answer 61

-lukasts

Question 62

block at LTD4

Answer 62

-lukasts

Question 63

Exercise induced asthma

Answer 63

Montelukast

Question 64

Allergic rhinitis

Answer 64

Montelukast

Question 65

Phosphodiesterase inhibitor

Answer 65

-phyllines

Question 66

SE: toxicities > excitatory effects in heart

Answer 66

-phyllines

Question 67

MOA: reduces serum IgE

Answer 67

Omalizumab