Anti-coagulation Flashcards Preview

Pharmacology (5th year) > Anti-coagulation > Flashcards

Flashcards in Anti-coagulation Deck (18):
1

Indications of a PE

- D-dimer
- Wells score
- S1Q3T3 (RV strain pattern on ECG)

2

Problems with LMWH

- can't give it to people at risk of bleeding, because you can't stop the bleeding

3

MOA of LMWH

Affects factor 10A

4

WHo do you need to monitor with LMWH?

- pregnant women with valvular heart disease

5

MOA of unfractionated heparin

- potentiates anti-thrombin 3

6

Monitoring required for unfractionated heparin

PTT monitoring

7

How to reverse unfractionated heparin

Protamine sulphate

8

How is unfractionated heparin given?

IV infusion

9

Adverse effects of unfractionated heparin

- > 5 days, heparin induced thrombocytopenia
- osteoporosis if longterm (dialysis patients)

10

Why give heparin before warfarin?

- warfarin takes 48-72 hrs to work

11

MOA of warfarin

Vit K antagonist

12

AE of warfarin

- bleeding
- warfarin skin necrosis
- purple toe syndrome (cholesterol emboli)

13

Causes of thrombophilai

- Factor 5 leiden
- Protein C+S def
- antiphospholipid syndrome

14

How to reverse warfarin

- Vit K
- FFP

15

Problems with warfatin

Lots of drug-drug interactions
- Rif
- NSAIDS
- alcohol
- diet

16

What to do if they bleed while on warfarin

- stop warfarin
- IV VIT K

17

What to do if they are warfarin toxic, but not bleeding

- give oral Vit K (1-2mg)

18

How to manage HIT

- hiridin (thombin inhibitor (direct)