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Pharmacology (5th year) > ARVs > Flashcards

Flashcards in ARVs Deck (21):
1

Nucleotide reverse transcriptase inhibitors

- Tenofovir
- emtricitabine
- abacavir
- lamivudine
- zidovudine
- stavudine
- didanosine

2

Non-nucleotide reverse transcriptase inhibitors

- efavirenz
- nevirapine

3

Protease inhibitors

- lopinavir
- atazanavir
- darunavir

4

Integrase inhibitors

- raltegravir
- dolutegravir

5

Thymidine analogues

- zidovudine
- stavudine

6

AEs of zidovudine

BM suppression
- anaemia
- neutropenia
- nausea
- headache
- myalgia

7

AEs of tenofovir

- renal toxicity

8

AEs of emtricitabine

- hyperpigmentation

9

AEs of didanosine

- pancreatitis
- peripheral neuropathy
- horrible taste

10

AEs of stavudine

- peripheral neuropathy
- hepatitis

11

AE of abacavir

- hypersensitivity reaction

12

Symptoms and signs of hyperlactataemia

- abdo discomfort/ LOW
- peripheral neuropathy
- hepatic steatosis
- tachycardia
- SOB

13

AEs of nevirapine

- rash
- hepatitis

14

AEs of efavirenz

- neuro stiff
- maculopapular rash
- teratogenic

15

General AEs of PIs

- diarrhoea
- hepatitis
- hyperlipidaemia (not TG)

16

AE of atazanavir

- hyperbilirubinaemia (unconj)

17

AEs of integrase inhibitors

- insomnia
- decreased WCC
- raised LFTs

18

Definition of first line failure

- 2 consecutive viral loads >1000 copies/ml

19

Drugs with high resistance

- efavirenz
- nevirapine
- lamivudine
- emtricitabine

20

CYTp450 inducers

- nevirapine
- efavirenz
- rifampicin

21

CYPTp450 inhibitor

- protease inhibiotrs