Anti-depressants Flashcards Preview

Block 3 Pharm > Anti-depressants > Flashcards

Flashcards in Anti-depressants Deck (34)
1

MEch of Amitriptyline

Increase 5-HT and NE in synpase
TCA

2

Major depressive disorder, chronic pain. Prevent Migraines

Amitriptyline

3

Side effects of amitriptyline or clomipramine (the TCAs)

Decreases REM/increases stage 4 sleep, anticholinergic, sedation, *cardiac abnormalities. Acute overdose -> hyperpyrexia, hyper- or hypotension, seizures, coma, cardiac conduction defects

4

Decreases REM/increases stage 4 sleep, anticholinergic, sedation, *cardiac abnormalities

amitriptyline/clomipramine
TCAs

5

Drug interactions of Amitriptyline

Drug interactions: Guanethidine, blocks its uptake. Sympathomimetic drugs. Effects many drugs absorption/metabolism (via slowed gastric times).

6

Amitriptyline's half life and its danger
(same for Clomipramine)

8-100 hours so can have OD

7

Clomipramine mech
(same as Amitriptyline)

Increase 5-HT and NE in synpase
TCA

8

Major depressive disorder, OCD (with SSRIs)

Clomipramine

9

Clomipramine uses

OCD adn MDD

10

Two SSRIs

Fluoxetine
Sertraline

11

Side effects of SSRIs

sexual dysnfuntion
sleep distrubance
Possible increased risk of suicide.

12

When are you at risk of seratonin syndrome?

Serotonin syndrome if SSRIS given with MAOIs.
*Less chance of SSRI withdrawal syndrome (long-acting, 7-day half-life)

13

Don't use ____ if on SSRIs

MAOIs

14

Major depression, affective disorders, OCD, panic disorder, social phobia, PTSD, GAD, PMS

SSRIs like Sertraline or Fluoxetine

15

which ssri is better for PMS

fluoxetine

16

" *Greater chance of SSRI withdrawal syndrome (short-acting)

Sertraline

17

SSRI: Increase 5-HT in synapse. Long acting

Fluoxetine

18

SSRI: Increase 5-HT in synapse. short acting

Sertraline

19

Mech of Bupropion

weakly blocks NET and DAT to increase DA and NE

20

weakly blocks NET and DAT to increase NA and DA

Bupropion

21

Depression, nicotine withdrawal, seasonal affective disorder

Bupropion

22

Uses of Bupropion

Depression, nicotine withdrawal, seasonal affective disorder

23

Depression, to increase appetite in AIDS patients

Mirtazapine

24

Mech of Mirtazapine

α2 autoreceptor antagonist to Increased 5-HT and NE in synpase

25

α2 autoreceptor antagonist to Increased 5-HT and NE in synpase

Mertazapine

26

Duloxetine is a

SNRI to block 5HT and NE reuptake

27

Depression. Also, neuropathic pain syndromes, fibromyalgia, back pain, osteoarthritis pain.

Duloxetine

28

Uses of Duloxetine

Depression. Also, neuropathic pain syndromes, fibromyalgia, back pain, osteoarthritis pain.

29

Duloxetine is contraindicated in pts with

liver disease

30

irreversible MAOI that Increasesd 5-HT, NE, and DA in synpase

Phenelzine

31

Use of Phenelzine

narcolepsy, affective disorders, depression

32

Acute toxicity: agitation, hallucinations, hyperpyrexia, convulsions, changes in BP.
Tyramine (fermented foods) -> HTN crisis (causes NE release).

Phenelzine

33

Dont eat _____ if on phenelzine

tyramine (fermented foods)

34

MAO is found in

mitochondria of neurons, liver, lungs, and other organs