Antibacterials I Flashcards Preview

Block 3 Pharm > Antibacterials I > Flashcards

Flashcards in Antibacterials I Deck (102)
Loading flashcards...
1

transported into the cell by an energy-requiring aerobic process (does not occuranaerobically)
• bind to several ribosomal sites, usually at 30S/50S interface; stops initiation, causes
premature release of ribosome from mRNA, and mRNA misreading
• post-antibiotic effect
• concentration-dependent killing

Aminoglycosides

2

aminoglycoside mechanism

binds to several 30S/50S interfce to stop initiation and causes premature release of ribosome from mRNA and mRNA mistreading

3

How do bacteria resist aminoglycosides?

enzymatic modification of the aminoglycosides

4

more effective against gram-neg. than gram-pos.
• poor activity against anaerobes
• primarily for gram-neg. ‘aerobic’ bacilli, incl. Enterobacteriaceae and Pseudomonas
aeruginosa

Aminoglycosides

5

aminoglycosides are better for gram negative or positive
for anaerobes or aerobes

gram negative
aerobes

6

due to toxicity, use restricted to serious infections in which other agents are unsuitable
• often used in conjunction with other agents (e.g. β-lactams)---- streptomycin

aminoglycosides

7

Gentamicin, tobramycin and amikacin are examples of

aminoglycosides

8

which aminoglycoside is most resistant to bacterial inactivation

amikacin

9

What four bacteria do aminoglycosides work great for

P.aeruginoa, Klebsiella, Enterobacter, Serratia

10

P.aeruginoa, Klebsiella, Enterobacter, Serratia are all suspeptible to what class of drugs

aminoglycosides used with B-lactams

11

How are aminoglycoside metabolized?

glomerular filtration

12

Adverse rxn of aminoglycosides

nephrotoxic and ototoxic and is related to dose and duration of therapy. less common is neuromuscular blockade

13

How are aminoglycosides administered?

IV or IM with poor penetration to CSF
*serious infection~~ combined with other antibiotics

14

MEch of Tetracyclines

transported into cell via carrier... binds to 30S ribosomal to stop attachment of aminoacly-tRNA to acceptor site
bacteriostatic

15

transported into cell via carrier... binds to 30S ribosomal to stop attachment of aminoacly-tRNA to acceptor site
bacteriostatic

tetracyclines

16

Modern tetracyclines such as _____ and ______ have longer 1/2 lives and are more lipophilic

minocycline and doxycycline

17

How does bacteria devo resistance to tetracyclines

increased transport of drug out of cells... resistant to one tetracylcine, likely resistant to all of them

18

Tetracyclines are no longer used bc

increased resistance

19

Preferred agents for rickettsia and chylamydia

Tetracyclines

20

Preferred agent for Mycoplasma and ureplasma and Borrelia (or lymes)

tetracyclines

21

alternative drug for syphilis and gonorrhea

tetracyclines

22

What can tetracyclines be used for

Rickettsia
Chylamydia
Mycoplasma and Ureaplasma
Borrelia
alt for gonorrhea and syphilis

23

You shouldn't used antacids with tetracycline because

the Ca++ in them will bind to tetracyclines and inhibit absorption

24

Adverse rxns to tetracyclines

GI disturbance, pseudomembranous enterocolitis, Candida superinfection, photosensitive, teeth discoloration, DONT USE IF PREGNANT

25

Tigecycline mech

binds to 30S and blocks aminoacyle-tRNA as well as other unique sites in ribosomes

26

This tetracycline doesn't have cross resistance with other antiBacts including tetracyclines

Tigecycline

27

Uses of Tigecycline by SITE

skin/skin strucutre infections
complicated intrabdominal infections
Community acquired pneumonia (CAP)

28

What pathogens are Tigecycline effective for

E.coli, Klebsiella, enterobacter but NOT psuedonomas
Staph (both MSSA and MRSA)
Bacteriodes
Clostridium perfringes
CAP: S. pneumoniae, Haemophilus

29

Drug to tx E.coli, Klebsiella, enterobacter but NOT psuedonomas

Tigecycline

30

Drug that can tx bacteriodes and Clostridium perfringes

Tigecycline