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Flashcards in Antiparasitics Deck (72)
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1

Random US parasites

Helminth infections in over 1 million
Toxocara (roundworms) from dogs and cas are 14%pop
malaria~2000 year
trichonomas vag~ 3 million
Giardia: 10% population

2

Infection of parasites associated with

poor economic conditions
encysted tapes in 25% inner city children and leading cause of seizures in kinds in hispanice

3

Cure vs control

have to eradicate several staes of parasite in host
-enZ unique to host and indespendible only to parasite

4

Nematode (roundworm) cycle

see eggs in feces--> then will hatch into a filiraform to pentrate skin and hang in our small intestine

5

Damages microtulbes
inhibits glycogen uptake
can't move or get E... DEATH you nasty roundworm!

Mebendazole
(mictrotubule destruction... now they can get glycogen and they can't move!)

6

effective for many intestinal roundworms and kills some ova... damages microtubules

Mebendazole

7

Use of Mebendazole

kills intestinal roundworms and some ova

8

Absorption of Mebendazole

low systemic bioavailability = low systemic toxicity

9

Albendazole uses

Echinococcus or cuteanous larval migrans and neurocystocerosis d/t Taenia solium

10

Used for echinoccosus or cutaneous larval migrans or neurocysticercosis due to Taenia solium

Albendazole
EICK.. they're all bendy under my skin and in my BRAIN!

11

same as mebendazole, liver -->albendazole sulfoxide (active)
good systemic distribution

Albendaozle
(EICK.. they're all bendy uder my skin and in my BRAIN!)

12

How is albendazole differenet from mebendazole

converted quickly be liver to active form for better distribution which is why is

13

Mech of Albendazole in depth

fuck with microtubules
inhibits glucose uptake
can't get food or move = die

14

What is special about albendazole metabolite

more activated by liver and great distribution

15

Side effects of Albendazole

duh.. elevates hepatic enZ bc converted in liver... and makes tummy hurt

16

affects energy metabolism via inhibition of mitochondrial fumarate reductase in HOOKWORMS

Thiabendazole
(tHiabendazole has an H... hookworms)

17

MEch of Thiabendazole for HOOKWORMS
(I'd be FUMING if i had hookworms)

affects E metabolism
inhibiting mitochondiral fumarate reductase in hookworms
(I'ld be FUMING if i had hookworms)

18

Mech of Thiabendazole for Strongyloidesl

inhibits assembly of parasitic microtubules.

19

Thiabendazole uses:

Strongyoids
cuteanous larva migrans from dog or cat hookworms

20

Strongyloides
cuteanous larva migrans from dog or cat hookworms

Thiabendazole

21

absorption of Thiabendazole

oral form rapidly absorbed

22

side effects of thiabendazole

nauseua, vomit, dizzy

23

Pyrantel Pamoate mechanism

depolarizing neuromuscular blocker, causing spastic paralysis of worm
Pyrantel Pamoate causes dePPPPPolarization and PPPPParalysis

24

uses of Pyrantel Pamoate

hookworm, pinworm, roundworm

25

increase Ca++ permeability.. causes muslce cnx... spastic paralysis

Praziquantel causes PPPPPPermeability

26

Mech of Praziquantel

increase Ca++ permeability.. causes muslce cnx... spastic paralysis
(PPPPPraziquantel... increase PPPPermeability)

27

drug of choice for Schisotosoma

Praziquantel
I pray this Schits over soon"

28

Use of Praziquantel

Schistosomiasis (also for taneia solium to prevent neurocysteriocorcosis)

29

Tape worm drugs

Praziquantel, Albendazole, Paromomycin sulfate

30

good activity for schistosomiasis but also for tania solium bc kills eggs to you can avoid cysticercosis

Praziquantel