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Flashcards in Generals on Opiods Deck (37)
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1

Endogenous Opioid. Precursor: POMC (as is ACTH). Found in hypothalamus, nucleus tractus solitarius, and ant. pituitary. (Runner's high).
Acuts on mu, delta

B endorphin

2

B endorphin is endogenous opoid with precursor

POMC
(to the MD)

3

B endorphin acts on which receptors

mu and delta
(BMD) from the POMC (it's precursor)

4

B endorphins are found in:

Found in hypothalamus, nucleus tractus solitarius, and ant. pituitary

5

Endogenous Opioid Dynorphin precursor

Prodynorphin.

6

Co-localizes with ADH in magnocellular cells of hypothalamus and post. pituitary.

Dynorphin
(aDh---Dynorphin)

7

Dynorphin colocalizes with :

ADH in magnocells

8

Dynorphin binds to

kappa

9

Endogenous Opioid Precursor of Enkephalin

Prokephalin.

10

Where is Enkephalin distributed?

Widely distrubuted in interneurons.
delta

11

Somatic pain. Sharp, localized pain. Terminate in lamina 1 and use glutamate.

A-Delta fibers

12

Visceral or neuropathic pain. Dull, diffuse, aching or burning pain. Terminate in lamina 2 and use glutamate AND substance P.

C delta fibers

13

Descending pain path Originate in _______

periaqueductal gray.

14

Descentind pain path Descend in

dorsolateral funiculus.

15

Point of descending pain path

Release NE, 5-HT, and Enkephalin to inhibit the ascending pathways

16

General on opiod receptors

All G-protein coupled -> Gi -> inhibit adenylate cyclase -> decrease cAMP. Inhibit neurotransmitter release

17

Pleasure in limbic.
Endogenous ligands: enkephalins, B-endorphins.
Drugs: morphine, fentanyl, methadone, meperidine, buprehorphine, others

Mu receptor

18

Mr receptor has endogenous ligans

enkephalins, b-endorpins

19

Pleasure in limbic.
Endogenous ligands: enkephalins, B-endorphins.
NO drugs.

Delta R

20

Dysphoria in limbic. Endogenous ligands: dynorphins. Drugs: butorphanol, pentazocine, nalbuphine

Kappa Receptors
(dysphoria--kappa--dynorphin)

21

Kappa preceptors cause:

dysphoria in limibc system(dynorphin--kappa--dysphoria)

22

Endogenous ligands for Kappa R

dynorphins

23

Drugs that produce a stuporous sleeplike stage and may or may not be analgesic

Narcotics

24

Opiates

Drugs that are derived from opium or have a morphinelike pharmacological profile

25

Refers to all opiates, agonist-antagonist, and endogenous peptides. Cause: analgesia, constipation, euphoria, sedation, resp. depression.

Opiods

26

Physical dependence is strong on opioids. Thus, ONLY type of chronic pain treated w/ opioids is cancer.

Opiod physical dependence

27

Duration of action related to both l

lipophilicity and elimination rate

28

Effect of opioids:
Antidiarrheal effect and constipation
a. Effects are both
b. Delay in gastric emptying, spasmodic increases in intestinal tone and decrease in propulsive movements.
c.____receptors on GI nerves.

central and peripheral
μ-

29

Opiods cause both: Euphoria – Rush and high and -___

sedation

30

Most serious side effect of opioid analgesics.

Respiratory depression