Opiod Drug I Flashcards Preview

Block 3 Pharm > Opiod Drug I > Flashcards

Flashcards in Opiod Drug I Deck (51)
1

Morphine works on what receptor

Mu agonist

2

4-5 hrs analgesia for mod to severe pain

morphine

3

Side effects of all Mu agonists

Constipation, euphoria, sedation, resp. depression, nausea, decreased LH release, increased ADH secretion (mu) or decreased (kappa), pupillary constriction

4

Has a large 1st pass in oral dose

morphine

5

Constipation, euphoria, sedation, resp. depression, nausea, decreased LH release, increased ADH secretion (mu) or decreased (kappa), pupillary constriction

side effects of all mu agonists

6

Can cause gall stones!

Fentanyl
(i would faint if i had gall stones!)

7

100x as potent as Morphine, short duration (1-1.5 hrs)

Fentanyl

8

Fentanyl uses:

100x potent as morphine and short duration
given as patch or IM

9

Used for moderate to severe pain. Conscious sedation (short-duration) as a patch or IM

Fentanyl
"its Fen-tastic!!! its 100x more potent AND i'm conscious"

10

Fentanyl works on which R

mu agonist

11

MOderate to severe pain but longer acting then morphine

methedone

12

because of it's longer duration... some concern with OD fatality and abuse

Methadone
methadone... you could be DONE :(

13

Forms toxic metabolite normeperidine

Meperidine
...NO..meperidine~ normeperidine = toxic

14

Moderate to severe pain.
Conscious sedation
(short-duration)

Meperidine (opioid)

15

Meperidine:
pain
type of sedation
duration

moderate to sevre
short duration
consious sedation

16

Contraindicated if you use Meperidine (opioid)

MAOIs

17

Prodrug, highly lipophilic and gets to brain quickly

Heroin (opioid)

18

weak mu agonist

Codeine

19

used for mild pain and is antitussive

codeine
---codeine for cough but a bitchy pain helper

20

uses of codeine

mostly antitussive, some pain relief and given in mixutre with acetominophen or aspirin

21

Pro-drug - some is metabolized to morphine. Antitussive.

Codeine

22

more efficacious then codeine and for moderate to severe pain

oxycodone

23

Oxycodone is a

mu agonist opioid

24

Sustained release oral (major abuse)

oxycodone

25

Codeine like efficacy for mild to moderate pain

Hydrocodone `aka Vicodin

26

opiod that is 2-3x as potent as Morphine

hydromorphone~~~ Mu agonist

27

Nalbuphine receptor actitivity:

mu antagonist,
kappa agonist

28

Mu antagonist, kappa agonist

Nalbuphine

29

Nalbuphine's efficacy profile

Similar to Morphine, but little euphoria and low abuse

30

Who would get nalbuphine?

used to precipitate opioid withdrawl

31

used to precipitate opioid withdrawl

nalbuphine or Buprenorphine

32

Delivery of Nalbuphine

IM only

33

Buprenorphine receptor activity

partial mu agonist

34

Given oral or as a patch to opioid dependents along with naloxone for opioid dependence

Buprenorphine

35

Naloxone (opioid antagonist) on what receptors

Mu antagonist, less so for kappa and delta

36

Only works when injected/crushed; not orally.
Thus, prevents abuse when given with opioid (buprenorphine). 1-2 hr duration.

Naloxone

37

How do we deliver naloxone

crushed/injected with opiod (buprenorphine)

38

Naloxone is most active:

given parenterally then orally

39

you mix this with buprenorphine to help with opiod withdrawl

Naloxone

40

Inhibits reward of opiates and alcohol. 24+ hr duration

Naltrexone

41

Naltrexone is a (receptro)

Mu antagonist
(na----TREX--one) trex aren't something we want... antagonist (vs naloxone are agonist)

42

What does Naltrexone do

inhibits the reward system of opioites

43

What drug tx alcohol and opioate abuse

naltrexone

44

Dextramethorphan works on what R

NMDA antagonist... antitussive
-dextramethorphaNNNNN.....NMDA

45

NMDA antagonist that is antitussive

Dextramethorphan (opioid related)

46

Weak Mu agonist, blocks NET and SERT

Tramadol (opioid related)

47

Tramadol R activity

weak Mu agonist and blocks NET and SERT
(transvestite because does both Mu agonist then NET and SERT)

48

Tramadol is used for

mild to moderate pain (oral and sustained release)

49

Combination of Buprenorphine and Naloxone to tx opioid dependence

Suboxone

50

Cough suppresants

Codeine, hydrocodone and dextromethorphan

51

Codeine and heroin are activated by

metabolism