Flashcards in Anti-emetic Drugs Deck (43)
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1
Transderm Scop: class
Anticholinergic
2
Transderm Scop: MOA
Blocks Ach activity at PNS sites in smooth muscle, secretory glands, and CNS
3
Transderm Scop: indications
Nausea, vertigo
4
Transderm Scop: side effects
Dry mouth, CNS depression
5
Transderm Scop: contraindications
Paraltyic Ileus, myasthenia gravis, narrow angle glaucoma
6
When should you apply Transderm Scop?
Well before you need it!
7
Phenergan: class
Phenothiazine
8
Phenergan: MOA
Blocks CNS D2 receptors and competes for H1 receptors
9
Phenergan: indication
Anti-emetic
Motion sickness
Sedation
10
Phenergan: side effects
Extrapyramidal sxs
Very sedating
11
Phenergan: contraindications
Parkingson's
seizure d/o
12
Haloperidol: class
Butyrophenone
13
Haloperidol: MOA
Blocks post synaptic mesolimbic D1/D2 receptors;
**Suppresses RAS
14
Haloperidol: indication
Anti-emetic
*but no one uses it for this in practice
15
Haloperidol: side effects
Agitation, akithesia, altered temp regulation, tardive dyskinesia
16
Reglan: class
Benzamide
17
Reglan: MOA
Blocks D and 5-HT receptors in CRTZ
18
Reglan: indication
Anti-emetic,
Diabetic gastroparesis
19
Reglan: side effects
Pseudo parkinsonism, tardive dyskinesia
20
Reglan: contraindication
Bowel obstruction
21
Dexamethasone: class
Corticosteroid
22
Dexamethasone: MOA
Enhances effect of 5-HT3 receptor antagonists in CRTZ
23
Dexamethasone: indication
Anti-emetic
24
Dexamethasone: side effects
With one dose - none really
25
When do you have to administer Dexamthasone in order for it to work?
Before you need it.
26
Marinol: class
Cannaboid
27
Marinol: MOA
Unknown
28
Marinol: indication
appetite stimulant,
Chemo-related antiemetic
29
What drug do you combine with Marinol to have a synergistic effect?
Phenergan
30
Zofran: class
Serotonin antagonist
31
Zofran: MOA
Peripheral and CRTZ 5-HT3 receptor blockade
32
Zofran: indication
post-op, radiation, and chemo-induced N/V
33
Zofran: side effect
Long QT
34
Which is more effective: scheduled Zofran or PRN?
Scheduled
35
Emend: class
NK-1 antagonist
36
Emend: MOA
Blocks central NK-1 receptors;
Augments anti-emetic effects of 5-HT3 receptor antagonists and corticosteroids
37
Emend: indication
Prevention of chemo induced and post-op N/V
38
Naloxegol: class
Peripheral acting opioid antagonist
39
Naloxegol: MOA
Mu opioid receptor antagonist coupled with PEG (helps not cross the BBB)
40
Naloxegol: indication
Opioid-induced constipation
41
Naloxegol: side effect
Hyperhydrosis
42
Naloxegol: Dx-Dx
CYP3A4 substrates
43
