Anti-emetic Drugs Flashcards Preview

GI Pharm > Anti-emetic Drugs > Flashcards

Flashcards in Anti-emetic Drugs Deck (43)
Loading flashcards...
1

Transderm Scop: class

Anticholinergic

2

Transderm Scop: MOA

Blocks Ach activity at PNS sites in smooth muscle, secretory glands, and CNS

3

Transderm Scop: indications

Nausea, vertigo

4

Transderm Scop: side effects

Dry mouth, CNS depression

5

Transderm Scop: contraindications

Paraltyic Ileus, myasthenia gravis, narrow angle glaucoma

6

When should you apply Transderm Scop?

Well before you need it!

7

Phenergan: class

Phenothiazine

8

Phenergan: MOA

Blocks CNS D2 receptors and competes for H1 receptors

9

Phenergan: indication

Anti-emetic
Motion sickness
Sedation

10

Phenergan: side effects

Extrapyramidal sxs
Very sedating

11

Phenergan: contraindications

Parkingson's
seizure d/o

12

Haloperidol: class

Butyrophenone

13

Haloperidol: MOA

Blocks post synaptic mesolimbic D1/D2 receptors;
**Suppresses RAS

14

Haloperidol: indication

Anti-emetic

*but no one uses it for this in practice

15

Haloperidol: side effects

Agitation, akithesia, altered temp regulation, tardive dyskinesia

16

Reglan: class

Benzamide

17

Reglan: MOA

Blocks D and 5-HT receptors in CRTZ

18

Reglan: indication

Anti-emetic,
Diabetic gastroparesis

19

Reglan: side effects

Pseudo parkinsonism, tardive dyskinesia

20

Reglan: contraindication

Bowel obstruction

21

Dexamethasone: class

Corticosteroid

22

Dexamethasone: MOA

Enhances effect of 5-HT3 receptor antagonists in CRTZ

23

Dexamethasone: indication

Anti-emetic

24

Dexamethasone: side effects

With one dose - none really

25

When do you have to administer Dexamthasone in order for it to work?

Before you need it.

26

Marinol: class

Cannaboid

27

Marinol: MOA

Unknown

28

Marinol: indication

appetite stimulant,
Chemo-related antiemetic

29

What drug do you combine with Marinol to have a synergistic effect?

Phenergan

30

Zofran: class

Serotonin antagonist

31

Zofran: MOA

Peripheral and CRTZ 5-HT3 receptor blockade

32

Zofran: indication

post-op, radiation, and chemo-induced N/V

33

Zofran: side effect

Long QT

34

Which is more effective: scheduled Zofran or PRN?

Scheduled

35

Emend: class

NK-1 antagonist

36

Emend: MOA

Blocks central NK-1 receptors;
Augments anti-emetic effects of 5-HT3 receptor antagonists and corticosteroids

37

Emend: indication

Prevention of chemo induced and post-op N/V

38

Naloxegol: class

Peripheral acting opioid antagonist

39

Naloxegol: MOA

Mu opioid receptor antagonist coupled with PEG (helps not cross the BBB)

40

Naloxegol: indication

Opioid-induced constipation

41

Naloxegol: side effect

Hyperhydrosis

42

Naloxegol: Dx-Dx

CYP3A4 substrates

43

To what dose do you reduce Naloxegol when the GFR falls below 60?

12.5mg/day