Antibiotics Flashcards
(10 cards)
What are the mechanisms how the antibiotics prevent micro-organisms?
1 - block synthesis of the bacterial wall
2 - inhibition of protein synthesis - attack bacterial ribosome
3 - disrupt the bacterial DNA
4 - block folate metabolism
What are the examples of antibiotics that block the synthesis of bacterial cell wall?
- beta lactams
- glycopeptides
What are the two types of antibiotic resistance?
- intrinsic resistance - eg absence of binding receptor
- acquired resistance - evolutionary/adaptive
What is the mode of action of beta lactams?
interfere with synthesis of the bacterial wall - prevents NAMA and NAG binding
What is the mode of action of macrolides?
Give an example of the drug.
- prevent bacterial protein synthesis by binding to 50s
- clarithromycin
What is the mode of action of quinolones?
- disrupt bacterial DNA
What is the mode of action of aminoglycoside?
Give an example of the drug.
- prevent bacterial protein synthesis by binding to 30s
- gentamicin
What is the mode of action of trimethoprim?
Inhibits folate synthesis
bacterial dehydrofolate reductase inhibitor
Which antibiotic can cause a black hairy tongue?
Tetracyclines
What is the treatment for legionella pneumonia?
Clarythromycin
