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Flashcards in Antibiotics: Cell wall inhibitors Deck (35):
0

Narrow spectrum penicillin used against Strep, pneumococcal, meningococcal infections?

Penicillin G - IV
Penicillin V - Oral
(Prone to inactivation by beta lactamases - degrade beta lactam ring)

1

MOA of beta lactam antibiotics?

Bind to PBP in cell wall to inhibit transpeptidation reaction that crosslinks cell wall PG

2

What drug prolongs action of pen by competing with renal tubular transporters?

Probenecid
Used in gout

3

Very narrow spectrum pen used against staphylococcal infections? (Penicillinase producing)

Methi, Naf, Oxa, Cloxacillin
"NAF for STAPH"
Excreted in bile
Given via IV due to poor absorption when given PO

4

Extended spectrum penicillin against Listeria and Enterococcus?

Ampicillin
Lista mo na si Ampi

5

Extended spectrum penicillin used as empiric treatment for otitis media, pneumonia, sinusitis?

Amoxicillin - greater ORAL bioavailability

6

Extended spectrum penicillin for moraxella and H. influenzae?

Co-amoxyclav

7

Ampicillin (Listeria) common AE?

Pseudomembranous colitis
Clostridium difficile
Treat with metro or vanco if life threatening

8

Clavulanic acid MOA?

Inhibits penicillinase, enhance activity of ampil and amox vs bacteria

9

ESPs work synergistically with what group of drugs?

Aminoglycosides
Ampi prevents restoration of holes in bacteria cell wall, allow AG to enter cell
Ampi Genta

10

Antimicrobial covering of ESP?

Ampicillin - Listeria. Enterococcus.
Coamox - Moraxella, H. influ
Proteus, E. coli, Salmonella

11

Penicillin for psedomonas? For enterobacter and kleb?

Pseudomonas - Ticarcillin - have antiplatelet activity, prone to bleeding
Enterobacter - Piperacillin

12

Antipseudomonal penicillins?

Takes Care of Pseudomonas
Ticarcillin
Carbenicillin
Piperacillin

13

Microbes covered by first gen ceph?

PEK
Proteus. E. coli. Klebsiella.

14

First gen ceph has same MOA as penicillins, usually used for?

Surgical prophylaxis
Bone infection (Cefazolin with good bone penetration)
Skin and soft tissue infections by staph and strep except MRSA

15

Mnemonic for First gen ceph?

Fader help me faz my PHarma

16

Difference of second gen ceph from first gen?

More resistant to beta lactamase.
Can cover more gram negative but still not effective against pseudomonas
Does not cross BBB

17

Microbial coverage of second gen?

HEN PEKS
H. influenzae, Enterobacter, Neisseria, Proteus, E. coli, Klebsiella, Serratia

18

Which second gen cause disulfiram like reaction?

Clara took PMT at PM
Cefamandole
Cefotetan

19

Second gen used as single dose treatment for neisseria?

Cefuroxime

20

Difference of third gen from second and first?

Decreased gram positive coverage. With anti-pseudomonas and anti-bacteroides activity
Synergistic with AG (first and second inc nephrotox with AG)

21

Third generation cephalosporin that causes disulfiram like reaction?

Clara took Pmt at pm
Cefoperazone

22

Mnemonic for third gen?

Fenge

23

Fourth gen ceph with wide coverage of gram positive and negative, resistant to beta lactamase?

Cefepime

24

Cephalosporins against Pseudomonas?

TAZ, FEP, FOPERA
Ceftazidime (3rd)
Cefepime (4th)
Cefoperazone (3rd)

25

Carbapenem that covers gram positive and negative bacteria, reserved for serious life threatening infections?

Imipenem
Meropenem
Ertapenem

26

What inhibits renal metabolism of imipenem?

Cilastatin
Kill is lastin' with cilastatin

27

Monobactam for infections by Klebsiella, Pseudomonas and Serratia? KlePS

Aztreonam
Resistant to beta lactamase

28

Beta lactamase inhibitor used with penicillin against strep, ecoli, haemophilus?

Clavulanic acid
Amoxiclav
Ampi Sulbac
Pip Tazo

29

Glycopeptide used for MRSA?

Vancomycin

30

Vancomycin AE?

Red man syndrome
Due to histamine release
(Prevent by slowing rate of infusion or give antiHis)

31

Vancomycin MOA?

Bind to D-Ala D-Ala terminus of peptidoglycan, also inhibit cell wall synthesis

32

What drug if resistant to vancomycin?

Linezolid

33

Peptide antibiotic reserved for topical use against gram positive organism?

Bacitracin
Marked nephrotox - topical only
vs Aztreonam - for gram negative

34

Antimetabolite used as second line drug for drug-resistant TB?

Cycloserine
Blocks incorporation of D-Ala to the PG