Antibiotics: Nuc Acid Synthesis Inhibitors Flashcards Preview

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Flashcards in Antibiotics: Nuc Acid Synthesis Inhibitors Deck (17)
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0

Sulfonamides classification into short intermed and long acting

Short - sulfaSoxazole
Intermed - intermetiate - sulfaMEThoxazole
Long - sulfaDOXine
Tagal maging doc!

1

Sulfonamide competitive inhibitor of what enzyme?
Trimethoprim?

Sulfo - dihydropteroate synthase (static) NOT found in mammals
Tri - dihydrofolate reductase (cidal)

"Sulfo-Static FoRed"

2

Sulfonamide used for burn infections?

Silver sulfadiazine

3

Silver sulfadiazine AE?

Acute hemolysis in G6PDD
SJS TEN

4

Bactericidal sulfonamide used for UTI, P.jiroveci pneumonia, toxoplasmosis, typhoid, shigellosis?

Co-trimoxazole

5

What CD4 count in AIDS favor p.jiroveci?

< 200

6

FQ inhibit what enzyme in DNA synthesis?

DNA gyrase in gram neg (unable to relax supercoiled DNA)
Topoisomerase in gram pos (unable to separate replicated DNA)

7

What exhibits postantibiotic effect?

Flouroquinolone
Aminoglycoside

8

First gen Flouroquinolone highly protein bound, stay in blood, used for UTI but no longer used?

Nalidixic acid

9

Second gen bactericidal Flouroquinolone for UTI, atypical pneumonia and second line for TB?

Ciprofloxacin
Oflox. Norflox

10

Ciproflox AE?

Tendinitis, tendon rupture
GI distress
Flouroquinolones hurt attachment to bones

11

Third gen Flouroquinolone for atypical pneumonia (myco, chlamyd, legionella)?

Levofloxacin

12

Levoflox AE?

Tendinitis
QT prolongation (Torsades)

13

Fourth gen Flouroquinolone with broad spectrum activity against gram pos, neg, anaerobes?

Moxifloxacin

14

Bactericial drug against anaerobic infections BELOW the diaphragm?

Metronidazole
Also for trichomonas and gardnerella vaginitis

15

Metronidazole AE?

Disulfiram
Clara took PMT at PM

16

DOC for UTI, safe for pregnant women?

Nitrofurantoin