Flashcards in Antibiotics: Nuc Acid Synthesis Inhibitors Deck (17)
Sulfonamides classification into short intermed and long acting
Short - sulfaSoxazole
Intermed - intermetiate - sulfaMEThoxazole
Long - sulfaDOXine
Tagal maging doc!
Sulfonamide competitive inhibitor of what enzyme?
Sulfo - dihydropteroate synthase (static) NOT found in mammals
Tri - dihydrofolate reductase (cidal)
Sulfonamide used for burn infections?
Silver sulfadiazine AE?
Acute hemolysis in G6PDD
Bactericidal sulfonamide used for UTI, P.jiroveci pneumonia, toxoplasmosis, typhoid, shigellosis?
What CD4 count in AIDS favor p.jiroveci?
FQ inhibit what enzyme in DNA synthesis?
DNA gyrase in gram neg (unable to relax supercoiled DNA)
Topoisomerase in gram pos (unable to separate replicated DNA)
What exhibits postantibiotic effect?
First gen Flouroquinolone highly protein bound, stay in blood, used for UTI but no longer used?
Second gen bactericidal Flouroquinolone for UTI, atypical pneumonia and second line for TB?
Tendinitis, tendon rupture
Flouroquinolones hurt attachment to bones
Third gen Flouroquinolone for atypical pneumonia (myco, chlamyd, legionella)?
QT prolongation (Torsades)
Fourth gen Flouroquinolone with broad spectrum activity against gram pos, neg, anaerobes?
Bactericial drug against anaerobic infections BELOW the diaphragm?
Also for trichomonas and gardnerella vaginitis
Clara took PMT at PM