Antidiabetics

Question 0

Uses of insulin?

Answer 0

DM
DKA
HyperK

Question 1

All insulin preparations contain what mineral?

Answer 1

Zinc

Determine duration of action

Question 2

Common AE of insulin?

Answer 2

Hypoglycemia

Lipodystrophy at injection site

Question 3

First gen sulfonylurea for T2DM?

Answer 3

Chlorpropamide

Close K channels, depolarization, release insulin

Question 4

Chlorpropamide AE?

Answer 4

Disulfiram
Clara took PMT in PM
Chlorprop. Cefoperazone. Tetan. Metronidazole

Question 5

Second gen sulfonylurea for T2DM that cause less hypoglycemia?

Answer 5

Glipizide

Question 6

Second gen sulfonylurea for T2DM that cause cholestatic jaundice?

Answer 6

Glibenclamide

GLIVERencamide

Question 7

Insulin secretagogue for those with sulfa allergies? For postprandial hypergly

Answer 7

Repaglinide

“REPel allergies after eating seafood!”

Question 8

Meglitinide with the least incidence of hypogly that can be used in patients with CKD?

Answer 8

Nateglinide

Nate archibald, least hypogly :)

Question 9

Biguanide that inhibit hepatic and renal gluconeogenesis? DOC for obese patients

Answer 9

Metformin

Question 10

Metformin also used in?

Answer 10

PCOS

Question 11

Side effect of metformin due to dec glucose absorption in the GIT?

Answer 11

Vit B12 malabsorption

Question 12

Thiazolidinedione that reduces mortality and macrovascular events in DM such as MI and stroke?

Answer 12

Pioglitazone

Pinapayongan yung heart - protects

Question 13

Thiazolidinedione MOA?

Answer 13

Enhance muscle and adipose tissue reuptake of glucose by activating PPAR gamma

Question 14

Thiazolidinedione that cause cardiovascular disease?

Answer 14

Rosiglitazone

Rosy has a heart problem

Question 15

Thiazolidinedione withdrawn from the market due to hepatotoxicity?

Answer 15

Troglitazone

Trolls are removed!

Question 16

Alpha glucosidase inhibitor MOA?

Answer 16

Prevent conversion of complex carbs to simple sugars, slow absorption in the GIT

Question 17

Alpha glucosidase inhibitor used for diabetes prevention can cause what AE?

Answer 17

Flatulence, diarrhea, abdominal pain

Question 18

Alpha glucosidase inhibitor with minor glucose lowering action?

Answer 18

Acarbose

Question 19

Amylin analog that suppress glucagon release, delay GI emptying and is anorectic?

Answer 19

Pramlintide

Question 20

GLP-1 agonist that produces early satiety administered as injectable preparation with metformin?

Answer 20

Exenatide

Uneeksena kasi busog na!

Question 21

DPP-4 inhibitor that degrade GLP-1 for T2DM?

Answer 21

Sitagliptin

Question 22

Popular antiobesity drug that inhibit pancreatic lipases?

Answer 22

Orlistat

Question 23

Common AE of Orlistat?

Answer 23

Malabsorption of ADEK
Rebound weight gain upon discontinuation
Not for pregnant women!!

Question 24

Antiobesity drug withdrawn from the market due to significant risk of stroke and CV events?

Answer 24

Sibutramine

Question 25

Antiobesity drug withdrawn from the market due inc risk of suicides and depression?

Answer 25

Rimonabant | Block cannabinoid receptor, anorectic

Question 26

Adverse effect of bangkok pills?

Answer 26

Valvular heart disease Fenfluramune Phentermine Ephedrine

Question 27

Effect of PTH on Ca and Mg? On bone?

Answer 27

HyperCa, hypoPO4 (trashing hormone) Low intermittent - blast, build bone High dose - inc bone resorption

Question 28

Recombinant PTH used for osteoporosis?

Answer 28

Teriparatide | Tara pare build tayo ng bone

Question 29

Inactive vit D used for rickets (children) and osteomalacia (adults)?

Answer 29

Ergocalciferol | AE: both hyperCa and hyperPO4

Question 30

Active vit D used for CKD (secondary hyperparathy due to dec Ca, inc PTH), liver disease and hypoparathyroidism?

Answer 30

Calcitriol

Question 31

Peptide hormone secreted by parafollicular C cells used for Paget's and in hyperCa?

Answer 31

Calcitonin

Question 32

Calcitonin used as a marker of what cancer?

Answer 32

Medullary thyroid cancer

Question 33

Net effect of calcitonin on Ca and PO4?

Answer 33

Decrease serum Ca and PO4 by inhibiting bone resorption

Question 34

Bisphosphonate that suppress activity of osteoclasts used in pagets and osteoporosis?

Answer 34

Alendronate

Question 35

AE of bisphosphonates? (100%)

Answer 35

Esophagitis | Drink large quantities of water and avoid esophageal reflux

Question 36

Alendronate contraindicated in?

Answer 36

Renal impairment, PUD, esophageal motility disorders

Question 37

Phosphate binding resin used for hyperphos in CKD and in Vit D intoxication?

Answer 37

Sevelamer | Can reduce uric acid levels also