Opioid Antagonists Flashcards Preview

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Flashcards in Opioid Antagonists Deck (15):
1

Opioids with shortest half life? Longest half life?

Shortest - Remifentanil 3-4mins
Longest - Buprenorphine 4-8hours

2

Function of opioid receptors?

Mu "Mabagal huminga" (Respiration)
DelTa "Tolerance"
Kappa "Konstipation"

3

Full agonist opioid analgesic (Mu) that exerts hemodynamic effects on pulmonary circulation? Used for severe pain, chest pain in MI

Morphine
(Miosis, Ortho hypo, Resp depression (Mu), Pain relief, His release, ICP increase, Nausea, Euphoria)

4

Most potent full agonist opioid analgesia? Used in breakthrough cancer pain and severe chronic pain (as lollipop)

Ohmefentanyl (OH MY FENTANYL)
18,000 times more potent

5

Opioid of choice for pancreatitis? Mu and Kappa

Meperidine
(no biliary spasm)

6

Meperidine fatal if combined with?

Selegiline

7

Meperidine cause serotonin syndrome if combined with?

MAOI
SSRI

8

Opioid partial agonist also used for cough suppression?

Dextromethorphan
(decreased sensitivity of cough receptors)

9

Opioid analgesic that causes drug induced hyperthyroidism? Investigated as novel treatment of leukemia

Methadone

10

Opioid analgesic used for post herpetic neuralgia and DM nephropathy?

Hydrocodone

11

Opioid analgesic withdrawn due to fatal cardiotoxicity? Group 1C

Propoxyphene
Commonly used in suicides

12

Opioid analgesic that reduce craving for alcohol? Effects are resistant to naloxone reversal

Buprenorphine

"Bukas Pre! Inom tayo"

13

Opioid antagonist for opioid overdose?

Naloxone

14

Tramadol contraindicated in patients with?

Epilepsy
Can produce seizures

15

Opioid overdose triad?

PCR
Pupillary constriction
Coma
Respiratory depression