Hyperlipidemia and Prostaglandins Flashcards Preview

Pharma > Hyperlipidemia and Prostaglandins > Flashcards

Flashcards in Hyperlipidemia and Prostaglandins Deck (37):
0

Hyperchylomicronemia associated with?

Acute pancreatitis

1

Raises TG and VLDL?

Alcohol

2

Reversible HMG Coa reductase inhibitor?

Simvastatin

"Simple lang to reverse"

3

MOA of simvastatin?

Decrease cholesterol synthesis
Increase LDL uptake in the liver by inc LDL receptors
Overall dec LDL levels

4

Why are statins used in ACS?

Stabilize plaque

5

Simvastatin AE?

Hepatotox.
GI distress.
Myopathy.
Rhabdomyolysis.

6

Statins Enhance risk of rhabdo and myopathy if given with?

Fibrates

7

When is the peak of cholesterol synthesis?

At night. Give statins ODHS.

8

How much of bile acids are reabsorbed? Returned back to?

90%
Enterohepatic circulation

9

Bile acid binding resin for hypercholesterolemia and pruritus in cholestasis?

Cholestyramine
Also for digitalis toxicity

10

AE Cholestyramine?

Constipation. Bloating. Gritty taste. Steatorrhea. Malabsorption.

11

Treat cholestyramine-induced constipation with?

Fiber supplements
Psyllium

12

MOA of bile acid binding resins?

Bind bile acids
Prevent reabsorption, increase use of hepatic cholesterol to synthesize new bile acid

13

Effect of BABR on LDL TG VLDL?

Modest decrease in LDL
Little or no effect on TG and VLDL

14

Where is cholesterol absorbed?

Jejunum
Via NPC1L1 transporter
Same transporter for physosterol

15

Selective inhibitor of NPC1L1 transporter to dec cholesterol absorption?

Ezetimibe
Used in cholesterolemia and physosterolemia

16

Ezetimibe AE?

Simvastatin + fibrates - myopathy and rhabdomyolysis
Simvastatin + ezetimibe - hepatotoxicity - synergistic in lowering LDL

17

Cholesterol analog, takes the place of cholesterol, dec absorption?

Sitosterol
AE: GI upset. Bloating

18

Most effective to inc HDL, reduce TG and VLDL?

Niacin

19

Effect on lipid profile of:
Statins
Fibrates
Nicotinic acid
Niacin

Statins dec LDL
Fibrates dec TG
Nicotinic acid inc HDL
Niacin dec VLDL

20

Niacin AE?

Flushing
Pruritus
Acanthosis nigricans
GI irritation

21

Pre treatment with this reduces flushing in Niacin?

Aspirin or NSAIDs

22

Contraindication of Niacin

PUD - may worsen

"NIce! Dala ka PUDs!"

23

Drugs that cause flushing?

VANC
Vancomycin. Adenosine. Niacin. CCB.

24

Activate PPAR alpha, increase synthesis of lipoprotein lipase, dec TG?
DOC for hyperTG

Gemfibrozil (Fibrates)

25

Fibrates inc expression of apoproteins:

Apo A1
Apo A2
To inc HDL levels

26

Fibrates at risk for what stones?

Cholesterol gallstones

27

Drugs used for the following:
Primary hyperchylomicronemia
Dec LPL and Apo C-II

Low fat diet
Niacin + fibrates
To dec TG

28

Familial hypercholes

Statins - first line to dec LDL
Plus niacin and ezetimibe

29

PGE1 analog that is used for PUD, prevention of NSAID induced bleed but is also an abortifacient?

Misoprostol
Activate EP receptors
Inc HCO3 and mucus secretion

30

Misoprostol causes what sequence?

Mobius sequence (teratogenic)

31

PGE1 analog to maintain patency of PDA?

Alprostadil

"open - Al Fresco"

32

PGE2 analog for cervical ripening? But also an abortifacient

Dinoprostone

33

Low/high concentrations of dinoprostone relax/contract uterus?

Low contract
High relax

34

PGF alpha analog for post partum hemorrhage?

Carboprost
WOF bronchoconstriction

35

PGF 2 alpha analog for glaucoma?

Latanoprost

36

PGI2 analog for pulmo hypertension? Reduce platelet aggregation in dialysis machines

Epoprostenol

"EPULMO"