Flashcards in Hyperlipidemia and Prostaglandins Deck (37)
Hyperchylomicronemia associated with?
Raises TG and VLDL?
Reversible HMG Coa reductase inhibitor?
"Simple lang to reverse"
MOA of simvastatin?
Decrease cholesterol synthesis
Increase LDL uptake in the liver by inc LDL receptors
Overall dec LDL levels
Why are statins used in ACS?
Statins Enhance risk of rhabdo and myopathy if given with?
When is the peak of cholesterol synthesis?
At night. Give statins ODHS.
How much of bile acids are reabsorbed? Returned back to?
Bile acid binding resin for hypercholesterolemia and pruritus in cholestasis?
Also for digitalis toxicity
Constipation. Bloating. Gritty taste. Steatorrhea. Malabsorption.
Treat cholestyramine-induced constipation with?
MOA of bile acid binding resins?
Bind bile acids
Prevent reabsorption, increase use of hepatic cholesterol to synthesize new bile acid
Effect of BABR on LDL TG VLDL?
Modest decrease in LDL
Little or no effect on TG and VLDL
Where is cholesterol absorbed?
Via NPC1L1 transporter
Same transporter for physosterol
Selective inhibitor of NPC1L1 transporter to dec cholesterol absorption?
Used in cholesterolemia and physosterolemia
Simvastatin + fibrates - myopathy and rhabdomyolysis
Simvastatin + ezetimibe - hepatotoxicity - synergistic in lowering LDL
Cholesterol analog, takes the place of cholesterol, dec absorption?
AE: GI upset. Bloating
Most effective to inc HDL, reduce TG and VLDL?
Effect on lipid profile of:
Statins dec LDL
Fibrates dec TG
Nicotinic acid inc HDL
Niacin dec VLDL
Pre treatment with this reduces flushing in Niacin?
Aspirin or NSAIDs
Contraindication of Niacin
PUD - may worsen
"NIce! Dala ka PUDs!"
Drugs that cause flushing?
Vancomycin. Adenosine. Niacin. CCB.
Activate PPAR alpha, increase synthesis of lipoprotein lipase, dec TG?
DOC for hyperTG
Fibrates inc expression of apoproteins:
To inc HDL levels
Fibrates at risk for what stones?
Drugs used for the following:
Dec LPL and Apo C-II
Low fat diet
Niacin + fibrates
To dec TG
Statins - first line to dec LDL
Plus niacin and ezetimibe