Flashcards in Antibodies Deck (59)
1
Monoclonal antiBs are
monospecific and identical
2
All therapeutic antiB's are
IgG
3
Most of the antibodies have a _______ Fc region and a ________ Fab region
human -umab
murine- momab
4
a mixed human/murine antiB is a
chimeric antiB
5
xi means
chimerci
6
zu means
humanized
7
suffix for all therapeutic antiBs is
mab
8
lim is fot
immune system
9
ci is for
cardiovascular
10
tu is for
tumor
11
vi is for
virus
12
Administration varries and are best given
IV
13
AnitBs are disctibuted
extracellularly
14
AntiB can cross BBB, T/F
False, too big
15
Protects IgG from degredation and proloungs the serum 1/2 life
Neonatal Fc REceptor for IgG
16
Helps transfer passive immunity to fetus
Neonatal Fc Receptor for IgG
17
What pH does FcRn bind the Fc regsion of IgG at?
pH lower then 6.5 so releases as 7.4
18
do murine IgG bind human FcRn?
no they don't
19
Fab antiB fragrements lacking Fc region will
not bind to FcRn
20
This protects the antiB from degredation once it's taken up into a cell
Neonatual Fc Receptor
21
Half life of IgG1, IgG2, IgG4 is
long or about 21 days
22
IgG3 half life it
7 days
23
antibody fragments Fab have T=1/2 of
.5-21 hours, very short
24
These cells have Fc receptors that can bind and causes endocytosis of IgG
phagocytic cells in target tissue
25
What is the function of renal and biliribin in degredation of antibodies?
unimportant
26
Uses for Monoclonal aniB therapy
immunosuppression
Autoimmune
malignancies
infectious diseas
asthma
27
Direct affect of antiBs on antiG
antagonism or neutralization
28
AntiB will bind and inactivate a
soluble antiG
29
Anitbody acts as competitive inhibitor of ligand by
binding to cellular recpetor
30
Blocking this guy will block neurovasculation
blocking VEGF
31
Blocking VEGF is good for
reducing vascularization of tumors
32
use to tx metastatic colorectal cancer, pancreatic cancer or breast and prostate carcinoma
VEGF blockig by antiB
33
This method of antiB binds and inhitibts EGF receptor to inhibit tumor growth
EGF
34
This antiB targets ______ to stop head and neck or colorectal cancer
EGF
35
By binding and inhibiting the EGF receotpr, the antiB is
inhibiting signaling
36
When would a Chimeric Fab fragment be useful
if we just want a short durationg of action
37
This is good for platele aggregation and inhibits fibrinogen
Chimeric Fab fragmet of mAb
38
therapies for Fab fragrment of mAG
acute coronary syndrome of percutaneous coronary intervention
39
By binding to the Fc Receptor on NK cell, the monoclonal anitB will activated
Anti-body dependent cellular cytotoxicity
40
Rituximab will bind to protein:
CD20
41
whhat is the significance of binding to CD20 on cell surface of B cells
causes B cell lysis when we have leukimic or lymphoma
42
CDC stands for
complement dependent cytotoxicity
43
AntiB bind to cell surface and Fc region binds to
complement protein to activate CDC
44
What is the result of CDC
cell lysis
45
What is a benefit of binding to or inhibiting EGF
we block EGF, get ACDD and CDC and inhibut tumor growth
46
To turn on antibody dependent cellular cytotoxicity (ADCC) we will activate which little guy
C3d
47
Selective delivery of toxins or radio nucleotides work by:
antiB-toxin --> antiB binds to target and is internalized--> toxin released
48
CD30 is a good target for Fab regions to bind to because
CD30 is not in normal cells but is expresed in lyphoma
49
CD30 specific antiB will also bring this along to release in these cells
microuble toin monomtl auristatin E or MMAE t
50
microtublue toxin-monomethy auristatin E is good for
bringing along with CD30 specific IgG because it will stop cell proliferation
51
A CD30 specific drug
Bretuximab vedotin
52
Bretuximab Vedotin works by
Cd3 speficif, has MMAE that stops cell porliferation and then promotes cellylar cytotoxicity and Anitbody dependendt cellular cytotoxicity
53
Ibritumomab tiuxetan Y labled antiB works agains what membrane protein
CD20
54
CD20 is on :
B cells
55
CD20 on B cells is targeted by
Ibritumomab that has a conjgated radioative Y
56
are monoclonal antiB well tolerated
yes.... generally safe
57
What are some side affects of this tx
mechanism specific, if tartes plateltes at risk for bleeding
if VEGF speciic, you can get tumor lysis syndrome or slow wound healing
58
The longer you tx with an immungenticy drug class
you lose the effect the the thearpy
59