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Flashcards in Antibodies Deck (59)
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1

Monoclonal antiBs are

monospecific and identical

2

All therapeutic antiB's are

IgG

3

Most of the antibodies have a _______ Fc region and a ________ Fab region

human -umab
murine- momab

4

a mixed human/murine antiB is a

chimeric antiB

5

xi means

chimerci

6

zu means

humanized

7

suffix for all therapeutic antiBs is

mab

8

lim is fot

immune system

9

ci is for

cardiovascular

10

tu is for

tumor

11

vi is for

virus

12

Administration varries and are best given

IV

13

AnitBs are disctibuted

extracellularly

14

AntiB can cross BBB, T/F

False, too big

15

Protects IgG from degredation and proloungs the serum 1/2 life

Neonatal Fc REceptor for IgG

16

Helps transfer passive immunity to fetus

Neonatal Fc Receptor for IgG

17

What pH does FcRn bind the Fc regsion of IgG at?

pH lower then 6.5 so releases as 7.4

18

do murine IgG bind human FcRn?

no they don't

19

Fab antiB fragrements lacking Fc region will

not bind to FcRn

20

This protects the antiB from degredation once it's taken up into a cell

Neonatual Fc Receptor

21

Half life of IgG1, IgG2, IgG4 is

long or about 21 days

22

IgG3 half life it

7 days

23

antibody fragments Fab have T=1/2 of

.5-21 hours, very short

24

These cells have Fc receptors that can bind and causes endocytosis of IgG

phagocytic cells in target tissue

25

What is the function of renal and biliribin in degredation of antibodies?

unimportant

26

Uses for Monoclonal aniB therapy

immunosuppression
Autoimmune
malignancies
infectious diseas
asthma

27

Direct affect of antiBs on antiG

antagonism or neutralization

28

AntiB will bind and inactivate a

soluble antiG

29

Anitbody acts as competitive inhibitor of ligand by

binding to cellular recpetor

30

Blocking this guy will block neurovasculation

blocking VEGF