Flashcards in Antibodies Deck (59)
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1
Monoclonal antiBs are
monospecific and identical
2
All therapeutic antiB's are
IgG
3
Most of the antibodies have a _______ Fc region and a ________ Fab region
human -umab
murine- momab
4
a mixed human/murine antiB is a
chimeric antiB
5
xi means
chimerci
6
zu means
humanized
7
suffix for all therapeutic antiBs is
mab
8
lim is fot
immune system
9
ci is for
cardiovascular
10
tu is for
tumor
11
vi is for
virus
12
Administration varries and are best given
IV
13
AnitBs are disctibuted
extracellularly
14
AntiB can cross BBB, T/F
False, too big
15
Protects IgG from degredation and proloungs the serum 1/2 life
Neonatal Fc REceptor for IgG
16
Helps transfer passive immunity to fetus
Neonatal Fc Receptor for IgG
17
What pH does FcRn bind the Fc regsion of IgG at?
pH lower then 6.5 so releases as 7.4
18
do murine IgG bind human FcRn?
no they don't
19
Fab antiB fragrements lacking Fc region will
not bind to FcRn
20
This protects the antiB from degredation once it's taken up into a cell
Neonatual Fc Receptor
21
Half life of IgG1, IgG2, IgG4 is
long or about 21 days
22
IgG3 half life it
7 days
23
antibody fragments Fab have T=1/2 of
.5-21 hours, very short
24
These cells have Fc receptors that can bind and causes endocytosis of IgG
phagocytic cells in target tissue
25
What is the function of renal and biliribin in degredation of antibodies?
unimportant
26
Uses for Monoclonal aniB therapy
immunosuppression
Autoimmune
malignancies
infectious diseas
asthma
27
Direct affect of antiBs on antiG
antagonism or neutralization
28
AntiB will bind and inactivate a
soluble antiG
29
Anitbody acts as competitive inhibitor of ligand by
binding to cellular recpetor
30
