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Flashcards in Antibodies Deck (59)
1

Monoclonal antiBs are

monospecific and identical

2

All therapeutic antiB's are

IgG

3

Most of the antibodies have a _______ Fc region and a ________ Fab region

human -umab
murine- momab

4

a mixed human/murine antiB is a

chimeric antiB

5

xi means

chimerci

6

zu means

humanized

7

suffix for all therapeutic antiBs is

mab

8

lim is fot

immune system

9

ci is for

cardiovascular

10

tu is for

tumor

11

vi is for

virus

12

Administration varries and are best given

IV

13

AnitBs are disctibuted

extracellularly

14

AntiB can cross BBB, T/F

False, too big

15

Protects IgG from degredation and proloungs the serum 1/2 life

Neonatal Fc REceptor for IgG

16

Helps transfer passive immunity to fetus

Neonatal Fc Receptor for IgG

17

What pH does FcRn bind the Fc regsion of IgG at?

pH lower then 6.5 so releases as 7.4

18

do murine IgG bind human FcRn?

no they don't

19

Fab antiB fragrements lacking Fc region will

not bind to FcRn

20

This protects the antiB from degredation once it's taken up into a cell

Neonatual Fc Receptor

21

Half life of IgG1, IgG2, IgG4 is

long or about 21 days

22

IgG3 half life it

7 days

23

antibody fragments Fab have T=1/2 of

.5-21 hours, very short

24

These cells have Fc receptors that can bind and causes endocytosis of IgG

phagocytic cells in target tissue

25

What is the function of renal and biliribin in degredation of antibodies?

unimportant

26

Uses for Monoclonal aniB therapy

immunosuppression
Autoimmune
malignancies
infectious diseas
asthma

27

Direct affect of antiBs on antiG

antagonism or neutralization

28

AntiB will bind and inactivate a

soluble antiG

29

Anitbody acts as competitive inhibitor of ligand by

binding to cellular recpetor

30

Blocking this guy will block neurovasculation

blocking VEGF

31

Blocking VEGF is good for

reducing vascularization of tumors

32

use to tx metastatic colorectal cancer, pancreatic cancer or breast and prostate carcinoma

VEGF blockig by antiB

33

This method of antiB binds and inhitibts EGF receptor to inhibit tumor growth

EGF

34

This antiB targets ______ to stop head and neck or colorectal cancer

EGF

35

By binding and inhibiting the EGF receotpr, the antiB is

inhibiting signaling

36

When would a Chimeric Fab fragment be useful

if we just want a short durationg of action

37

This is good for platele aggregation and inhibits fibrinogen

Chimeric Fab fragmet of mAb

38

therapies for Fab fragrment of mAG

acute coronary syndrome of percutaneous coronary intervention

39

By binding to the Fc Receptor on NK cell, the monoclonal anitB will activated

Anti-body dependent cellular cytotoxicity

40

Rituximab will bind to protein:

CD20

41

whhat is the significance of binding to CD20 on cell surface of B cells

causes B cell lysis when we have leukimic or lymphoma

42

CDC stands for

complement dependent cytotoxicity

43

AntiB bind to cell surface and Fc region binds to

complement protein to activate CDC

44

What is the result of CDC

cell lysis

45

What is a benefit of binding to or inhibiting EGF

we block EGF, get ACDD and CDC and inhibut tumor growth

46

To turn on antibody dependent cellular cytotoxicity (ADCC) we will activate which little guy

C3d

47

Selective delivery of toxins or radio nucleotides work by:

antiB-toxin --> antiB binds to target and is internalized--> toxin released

48

CD30 is a good target for Fab regions to bind to because

CD30 is not in normal cells but is expresed in lyphoma

49

CD30 specific antiB will also bring this along to release in these cells

microuble toin monomtl auristatin E or MMAE t

50

microtublue toxin-monomethy auristatin E is good for

bringing along with CD30 specific IgG because it will stop cell proliferation

51

A CD30 specific drug

Bretuximab vedotin

52

Bretuximab Vedotin works by

Cd3 speficif, has MMAE that stops cell porliferation and then promotes cellylar cytotoxicity and Anitbody dependendt cellular cytotoxicity

53

Ibritumomab tiuxetan Y labled antiB works agains what membrane protein

CD20

54

CD20 is on :

B cells

55

CD20 on B cells is targeted by

Ibritumomab that has a conjgated radioative Y

56

are monoclonal antiB well tolerated

yes.... generally safe

57

What are some side affects of this tx

mechanism specific, if tartes plateltes at risk for bleeding
if VEGF speciic, you can get tumor lysis syndrome or slow wound healing

58

The longer you tx with an immungenticy drug class

you lose the effect the the thearpy

59

Negative affect of antiB that triggers release of a variety of cytockines

cytokine storm