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Flashcards in Drug metabolism Deck (116)
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1

Processes that prevent continuous drug action

elimination/excreation
metabolism

2

Drug metabolites are usually more ________ then the drug ingested thus easliy excreated

poloar

3

most drugs enter the body _______ thus are difficult to excrete

lipophilic

4

In most cases metabolism will take active drug-->

inactive metabolite

5

A drug that is converted to active form by drug metabolizing enZ

prodrug

6

a prodrug is inactive until

metabolized

7

the more drugs we take the more at risk we are for

adverse affects

8

Drugs withdrawn from the market often d/t this reason

drug-drug interactions d/t drug metabolism

9

These guys do oxidation, reduction, dealkylation or hydrolysis

Phase I enZ

10

This enZ will often introdue or reaveal a functional group

Phase I enZ

11

Phase I enZ actions

oxidation, reduction, dealkylation or hyrolysis and introduce or reveal a functional group

12

These guys have conjugation of durg or durg metaboliet to endogenous substrate molecule

Phase II enZ

13

responsible for : Drug + conjugant--> Drug-conjugant

Phase II enZ

14

CYPs are examples of

Phase I enx

15

CYPs will often

make lipophilic drugs more soluble in water

16

These guys add large, polar conjugates to make drug super water soluble

phase II

17

Common location for drug metabolizing agents

portals of entry/exit
liver (HIGHEST)
GI, kidneys, lungs

18

Subcellularly where are the Phase I enZ located ?

In the SER microsomes

19

Subcellularly, where are phase II enZ located?

most are cytosilc

20

What venous system will take drugs to liver from the GI system

portal venous sytem

21

What drug administration is exposed to 1st pass effect

orally administered

22

Significant drug metabolism can occur before reaching general circulation d/t

first pass in intestines and liver

23

Drugs exposed to 1st pass will need _____ dose

higher

24

bioavialibty will ______ d/t first pass

lower F

25

F for IV administration

1 or 100%

26

What are two reasons for poor F

poor absorption or large first pass effect

27

Morphines's F d/t first pass

.33

28

If i gave IV dose of 10 mg of morphine to relieve pain, what oral dose would i need to match that?

30 mg

29

Two key Phase I enZ

Cytochrome P450s = CYPs
Flavin-containing monooxygenases

30

Cytochrome P450s and Flavin-containing monooxygenases are examples of:

Phase I enZ