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MCD- Immunology > Antibodies > Flashcards

Flashcards in Antibodies Deck (13):
1

3 process that antigen antibody complex can stimulate

Complement activation
Opsonisation
Cell activation by change in shape of Fc receptor when antigen binds

2

What are the Fab and Fc parts of an antibody

Fab = part that binds to antigen
Fc = part that is constant

3

What other disulphide bonds are found in immunoglobulin?

Internal intrachain disulphide bonds
(Within chains)

4

What are the three hypervariable regions called?

Complementary determining regions
CDR amino acids part of antibody that binds to antigen

Constant region = beta pleated sheets
CDR = end of V domains

5

What forces are involved in antibody antigen interactions?

Everything but COVALENT

6

Affinity vs avidity

Affinity = strength of interactions between ONE antigen binding site and ONE epitope

Avidity = strength of all interactions between antibody with MANY binding sites and antigen with MANY epitopes

7

What is cross reactivity?

Antibody for one antigen can bind to another that is similar e.g cow pox and small pox

8

IgG

Gamma heavy chain
4 types
Most abundant
Move across placenta
Activate complement by classical pathway
Sub groups vary in hinge region

9

IgA

Second most abundant
2 sub groups
Alpha heavy chain
Protects mucosal surfaces
Secretory molecules attached to it by J chain

10

How does dimeric IgA get across epithelial to lumen?

IgA produced by plasma cell
IgA binds to poly Ig receptor on basolateral membrane
Endocytosis into epithelial
Poly Ig receptor cleaved
Secretory component attached to IgA and secreted into lumen

11

IgM

Mew heavy chain
Pentameric
Joined by J chain
Agglutination

12

IgD

Delta heavy chain
Low conc in serum
Involved in B cell development

13

IgE

Epsilon heavy chain
Produced when allergic disease or parasitic infection
Bind to Fc receptor of mast cell and basophils