Regulation Of Lymphocyte Response Flashcards Preview

MCD- Immunology > Regulation Of Lymphocyte Response > Flashcards

Flashcards in Regulation Of Lymphocyte Response Deck (20):
1

What is an autoimmune disease?

Immune response against self antigens as they are recognised by MCHs

2

What is an immune mediated inflammatory disease?

Chronic disease with inflammation caused by lack of tolerance or regulation
Can be caused by antigens that look similar to self antigens
T cells or antibodies

3

What is an allergy?

Harmful immune response to non infectious agents
- mediated by IgE and mast cells releasing histamine
- T cells

4

What is hypercytokinemia and sepsis?

Too much immune response due to positive feedback
Hypercytokinemia = too many cytokines in blood
Sepsis = when bacteria enters blood

5

What 4 things can be caused by poorly regulated immune response?

Autoimmune disease
Allergies
Sepsis
Hypercytokinemia

6

How can these be treated?

By developing immunological tolerance to these agents

7

What is immunological tolerance?

Specific unresponsive ness to antigens that induce unnecessary immune response as if B recognise self antigen they could mutate to recognise it better which is dangerous for us

8

What are central and peripheral tolerance?

Central =destroy self reactive T and B before they enter circulation
Peripheral = destroy self reactive T and B that don’t enter circulation

9

What is AIRE?

Autoimmune regulator allows thymus to express the genes that update expressed in all peptides in peripheral tissue
This means that T cells can be tolerant to all self cells

10

What does a mutation in AIRE cause ?

Autoimmune polyendocrinopathy synth drone type 1

11

What are the 4 mechanisms for peripheral tolerance?

Anergy
Ignorence
Deletion
Regulation

12

Anergy

Absence of costimulator signal so naive T cell cannot be activated

13

Ignorance

In sites where risk of inflammation is greater than risk of infection
There are not APC so no activation

14

Deletion

T cell express Fas ligand = apoptosis of T cell

15

Regulation

By Treg
Produces cytokines IL10 to inhibit self reactive T and ACPs pres t antigens like in anergy

16

Treg express which transcription factors?

FoxP3

17

Phenotype of Treg

CD4, IL10, FoxP3

18

2 types of Treg

Natural = develop in thymus, in peripheral tissue
Inducible = when exposed to APC go from helper T to Treg

19

Resolution vs repair

Resolution = No scar tissue, back to normal
Repair = scar tissue and regeneration

20

What can be suoressed by amino acid starvation?

T cells