Anticholinergic Drugs

Question 1

natural sources of atropine

Answer 1

Deadly Nightshade (atropa belladonna)

jimson weed

jameson weed

Question 2

Natural Alkaloids

Answer 2

Atropine, Hyoscine (Scopolamine)

Question 3

Semisynthetic derivatives

Answer 3

Ipratropmium bromide

Tiotropium bromide

Question 4

Quaternary Compounds

Answer 4

Glycopyrrolate

Question 5

Tertiary Amines

Answer 5

Dicyclomine

Question 6

Antiparkinsonian

Answer 6

Trihexyphenidyl

Benztropine (Park my Benz)

Question 7

Atropine effects on CNS

Answer 7

anti motion sickness property

Suppresses tremor and rigidity of parkinsonism

Question 8

Atropine effects on heart

Answer 8

Blockade of M2 receptors on SA node: increases HR

Question 9

Atropine effects on eyes

Answer 9

Mydriasis
photophobia
cycloplegia
increased IOP

Question 10

Atropine effects on glands

Answer 10

M3 blockade

Question 11

Atropine effects on body temperature

Answer 11

increased due to inhibition of sweating

children are more sensitive - atropine fever

Question 12

Ipratropium bromide

Answer 12

More effective in COPD than in bronchial asthma

Ipratropium - I Pray I could breath

Question 13

Dicyclomine

Answer 13

Antispasmodic

Question 14

Oxybutynin

Answer 14

urinary bladder

M1/M3

Question 15

Drotaverine

Answer 15

Inhibit PDE4 ->

↑ cGMP & cAMP

Question 16

glycopyrrolate

Answer 16

prevent reflex laryngospasm

Question 17

pirenzepine, telenzepine

Answer 17

Peptic Ulcer

Question 18

darifenacin

Answer 18

Hyperhydrosis

Question 19

dicyclomine

Answer 19

excessive salivation

Question 20

Atropine methonitrate, dicyclomine

Answer 20

Intestinal and renal colic

Question 21

loperamide, diphenoxylate + atropine

Answer 21

Nervous and drug induced diarrhoea, functional diarrhea

Question 22

oxybutynin, flavoxate

Answer 22

Urinary urge incontinence, enuresis

Question 23

Ipratropium bromide & tiotropium bromide

Answer 23

COPD

Question 24

mydriatic and cycloplegic: To test error of refraction

Answer 24

tropicamide

Question 25

mydriatic and cycloplegic: In Fundoscopy

Answer 25

phenylephrine

Question 26

Treatment of iridocyclitis/ iritis/uveitis

Answer 26

homatropine

Question 27

cardiac vagolytic

Answer 27

atropine

Question 28

Prophylaxis for Motion/Sea sickness

Answer 28

hyoscine ***

Question 29

Parkinsonism

Answer 29

Benztropine

Question 30

Anticholinesterase (oraganophosphate) poisoning & early type of mushroom poisoning

Answer 30

atropine

Question 31

Neostigmine therapy in myasthenia gravis

Answer 31

atropine to block muscarinic side effects

Question 32

Major difference between atropine & hyoscine

Answer 32

at low doses, atropine is CNS excitant whereas hyoscine is depressant

Question 33

Atropine overdose

Answer 33

``` Hot as a hare Dry as a bone Red as a beet Blind as a bat Mad as a hatter Tachycardia ```

Question 34

Contraindications of atropine therapy

Answer 34

narrow iridocorneal angle BPH in elderly