Midterm Flashcards by Emilee Gwyn

Q

drug biotransformation

A

non-polar to POLAR

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Q

pharmacogenomics

warfarin toxicity

A

vitamin k ->
epoxide reductase ->
*CYTO P450

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Q

alkalinize urine

A

NaHCO3

*decreases tubular absorption

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Q

Vd=

A

dose administered / plasma drug concentration

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Q

drug that crosses membrane

A

steroid

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Q

EC50 vs Kd

A

EC50 < Kd

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Q

IND step in drug development

A

comes after animal studies, but before human studies (phase 1)

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Q

thalidomide

A

phecomelia

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Q

drug/food interaction

A

effects absorption

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Q

arsenic poisoning, black urine

A

Dimercaperol

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Q

inhibits ACh

A

Botulinum toxin

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Q

Pilocarpine

A

M3 stimulation

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Q

organophosphate chemical antagonist

A

Pralidoxime

contraindicated in carbamate poisoning

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Q

Timolol

A

Beta blocker

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Q

Varenicline

A

agonist at Nicotinic alpha4/beta2

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Q

atropine (receptor type)

A

anti-muscarinic receptor

muscarinic antagonist

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Q

Benzotropine

A

Parkinson’s Disease

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Q

atropine side effect

A

decreased sweating

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Q

anti-spasmotic

Study These Flashcards

A

dicyclomine

Q

COPD

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A

Ipratropium Bromide

Q

mydriatic and cycloplegia

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A

*test error of refraction

Tropicamide

Q

Clonidine

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A

*alpha2 agonist

HTN and Renal disease

Q

epinephrine

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A

biphasic (decreased beta2, increased alpha1)

Q

CHF

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A

stimulate Beta1

BPH

alpha1 antagonism (prazosin)

alpha selective at bladder trigone

Tamsulosin

decreases diastolic, but no effect on systolic

beta2

contraindication for non-selective Beta blocker

asthma

physiological antagonist of histamine

epinephrine

1st generation antihistamine

crosses BBB | *block H1 in RAAS

lanoprost

PGF2alpha analogue

mechanism of sumatriptan

*5HT-1D/1B | migraines

loop diuretics Na/K/Cl co-transport side effects

alkalosis

resistant HTN

add Hydrochlorothiazide

spirolactone

used in Liver Cirrhosis

spirolactone causes

hyperkalemia

diabetes insipidus

Desmopressin

cardio-selective Beta1 blocker

Atenolol

calcium channel blockers

- dipines | nifedipine: decreases BP, cardiac use

HTN in pregnancy

*Labetalol | or methyldopa

Postural Hypotension

Alpha1 blockers

``` increases vascular resistance increases muscle increases renal increases MAP decreases HR ```

NE

COPD

M3

urinary side effects, antimuscarinic

COPD

affects drug

dimished hepatic metabolism

?? enzyme induction ??

drug-drug interaction

inhibits NE

cocaine, TCA