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SRNAPharmacology II > Anticholinergic Drugs > Flashcards

Anticholinergic Drugs Flashcards

(50 cards)

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1
Q

Anticholinergic drugs class

A

Competitive antagonists for Ach at muscarinic cholinergic receptors for in heart, salivary glands and smooth muscle of GI

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2
Q

Tertiary amine drug (2)

A

Atropine and Scopolamine

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3
Q

Quarternary amine drug

A

Glycopyrrolate

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4
Q

Which one types are unionized and cross BBB

A

Atropine

Scopolamine

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5
Q

Anticholinergic ONLY WORK at

A

MUSCARINIC receptors.

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6
Q

MOA of anticholinergic

A

combine reversibly with muscarinic receptors and

Prevent access of ACH to receptor site

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7
Q

Five subtypes of muscarinic

A

M1, M2, M3, M4, M5

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8
Q

Atropine affects

A

All Ms receptors

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9
Q

M1 found in

A

CNS and stomach

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10
Q

M2 found in

A

CNS and heart

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11
Q

M3 found in

A

Salivary glands
Airway smooth muscles
SALIVATION

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12
Q

M4 found in

A

CNS and heart

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13
Q

M5 found in

A

CNS

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14
Q

Effects on M2

A

Bradycardia

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15
Q

With those agents, doses needed to affect the heART.

A

Larger doses to affect the heart.

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16
Q

FIRST EFFECTS OF ANTICHOLINERGIC IS ON

A

SALIVARY GLANDS

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17
Q 
*****Comparative effects : Greatest and least effect
Sedation\_\_\_\_\_\_\_\_\_\_
Antisialagogue \_\_\_\_\_\_\_\_\_
Heart
Smooth muscle
A

Compare

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18
Q

Greatest SEDATIVE PROPERTY

A

SCOPOLAMINE

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19
Q

NO sedative

A

GLYCOPYRROLATE

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20
Q

If you don’t want any HR increase or stimulation

A

GLYCOPYRROLATE

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21
Q

GREATEST effects on heart

22
Q

You don’t want Any IOP (avoid in glaucoma)

Study These Flashcards
A

GLYCOPYRROLATE

23
Q

Worst effect on IOP (increase)

24
Q

Motion- induced sickness BEST

25
Motion sickness WORST
GLYCOPYRROLATE
26
100 times more potent than atropine as a sedating
SCOPOLAMINE
27
Not to be use in elderly, why?
SCOPOLAMINE; increase confusion, agitation
28
Fastest onset of action
1 minute | DOA 30-60 minutes
29
Does glycopyrrolate cross BBB? why not?
No; quaternary compound
30
Atropine metabolism and excretion
liver | urine
31
Anticholinergic use (2)
Prevent bradycardia | Sedative and antisialalogue effects
32
Less effect on pupil size_______
Glycopyrrolate
33
They can use as _______
Bronchodilators because they BLOCK parasympathetic NS
34
Dose of scopolamine for sedation
0.3-0.5mg IM
35
Central anticholinergic syndrome
ranging from restlessness to somnolence Elderly patients more sensitive ESPECIALLY with SCOPOLAMINE
36
What can potentiate anticholinergic syndrome
VA
37
What agent to reverse CNS effects of tertiary amine?
PHYSOSTIGMINE 15-60mcg/kg
38
Anticholinergic can
Decrease barrier pressure
39
Atropine and glycopyrrolate can
Decrease LES pressure
40
TREATMENT of REFLEX-MEDICATED BRADYCARDIA
Atropine 15-70 mcg/kg IV | most rapid onset
41
Atropine use with _______reversal agent
EDROPHONIUM
42
Glycopyrrolate use with _______reversal agent
NEOSTIGMINE
43
ATROVENT
Derivative of atropine Quarternary compound slow onset of action Less effective than albuterol
44
Anticholinergic in the eye causes
MYDRIASIS and CYCLOPLEGIA
45
Patients with GLAUCOMA should not be given
SCOPOLAMINE
46
Anesthesia implications : SCOPOLAMINE
Effective in tx of N/V associated with morphine PCA and epidurals
47
Prophylactive TD scopolamine
applied evening before decreases nausea associated with laparoscopy in GA.
48
Symptoms of Anticholinergic OVERDOSE
``` Dry mouth Blurred vision Photophobia TACHYCARDIA Dry flushed ksin Rashes ```
49
Treatment of OVERdose is
Physostigmine 15-60 mcg/kg IV
50
Symptoms CNS overdose
CNS | Seizures, coma and medullary ventilatory center paralysis

SRNAPharmacology II (32 decks)

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