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2 Cardiovascular > Anticoagulants > Flashcards

Flashcards in Anticoagulants Deck (11)
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1
Q

What does a thrombus in the venous circulation consist of…

Why are anticoagulants no good for arterial curculation

A

Fibrin web enmeshed with platelets and red cells

…in the arterial circulation thrombus is mainly platelets and little fibrin

2
Q

Which has a longer duration of action… LMWH or UFH

A

LMWH

3
Q

What is the advantage of UFH

A

Shorter duration of action so use in high risk as effect rapidly terminated by stopping transfusion

4
Q

LWWH : name three

A

Dalteparin
Enoxaparin
Tinzaparin

5
Q

Why are LMWH preferred for prevention of DVT (3)

A

No monitoring
Lower risk of heparin induced thrombocytopenia
Once daily admin is usually fine

6
Q

What is a role of LMWH in cancer

A

Dalteparin and Tinzaparin licenced for extended prophylaxis of DVT in patients with solid tumours (6 months)

7
Q

Role of her paring in maintaining the patently of peripheral venous catheters?

A

Apparently sodium 0.9% is as effective

For arterial and central catheters the role is unclear
According to the BNF…

8
Q

Fondaparinux mode of action

A

Synthethic pentasacarride that inhibits activated factor X

9
Q

Asinine contraindicated under what age? Except….

A

16

When specifically indicated such as kwasaki syndrome or high risk of stroke

10
Q

Interactions with aspirin (4)

A

NSAIDs -s/e
SSRI & venlafaxine- bleed
Methotrexate - reduced renal excretion of methotrexate
Acetozolamide (diuretic)

11
Q

Symptoms of aspirin overdose

A
Tinnitus 
Hyperventilation
Deafness 
Vasodilation
Sweating