Betablockers Flashcards Preview

2 Cardiovascular > Betablockers > Flashcards

Flashcards in Betablockers Deck (14):
1

beta blockers block betaadrenoreceptors in what areas of the body

heart, peripheral vasculature, bronchi, pancreas and liver

2

what is intrinsic sympathomimetic activity?
what is the clinical implication? (2)

the capacity of betablockers to stimulate as well as blockadrenergic receptors
(partial agonists)
beta blockers with ISA - cause less bradycardia and coldness of extrematies

3

what beta blockers have intrinsic sympathomimetic activity (4)

oxprenolol
pindolol
acebutolol
celiprolol

4

which beta blockers are the most water soluble (4)?
what is the implication of this? (2)

atenolol, celiprolol, nadolol, sotolol

- less likely to cross the BBB therefore cause less sleep disturbance/nightmares
-may need dose adjustment in renal failure

5

why should we caution betablockers in asthma

percipitation of bronchospasm - however some patients may still need the betablocker

6

what betablockers whould we chose if an asthma patient NEEDs a beta blocker

cardioselective ones
(e.g. bisoprolol, atenolol, metoprolol, nebivolol)

7

why caution betablockers in diabetes

reduced warning of hypos (masks tachycardia)
may cause hypos/hypers by interfering in carb metabolism (in patients with or without diabetes)
-not entirely contraindicated
-even more caution if combined with thiazide like diuretic

8

betablockers are good at reducing BP so why are other antihypertensives generally preferred for uncomplicated hypertension?

they are shown to be more effective in reducing incidence of stroke, MI and CV mortality

9

in pheochromocytoma (adrenaline secreting tumour) what should be given with a betablocker to control pulse

phenoxybenzamine (alpha blocker)

(jut blocking beta can lead to hypertensive crisis)

10

risks of abrupt withdrawl of betablockers (2)

rebound angina for pt with angina
worsening of ischaemia in IHD

11

risks of using betablockers with verapamil

percipitation of HF

12

what is the betablocker of choice in thyrotoxicosis

propranolol

13

what skin condition are betablockers cautioned in

psoriasis - may trigger flare

14

symptoms of beta blocker overdose

sycope
lightheadedness
dizziness
bradycardia
hypotension