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2 Cardiovascular > Betablockers > Flashcards

Flashcards in Betablockers Deck (14)
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1
Q

beta blockers block betaadrenoreceptors in what areas of the body

A

heart, peripheral vasculature, bronchi, pancreas and liver

2
Q

what is intrinsic sympathomimetic activity?

what is the clinical implication? (2)

A

the capacity of betablockers to stimulate as well as blockadrenergic receptors
(partial agonists)
beta blockers with ISA - cause less bradycardia and coldness of extrematies

3
Q

what beta blockers have intrinsic sympathomimetic activity (4)

A

oxprenolol
pindolol
acebutolol
celiprolol

4
Q

which beta blockers are the most water soluble (4)?

what is the implication of this? (2)

A

atenolol, celiprolol, nadolol, sotolol

  • less likely to cross the BBB therefore cause less sleep disturbance/nightmares
  • may need dose adjustment in renal failure
5
Q

why should we caution betablockers in asthma

A

percipitation of bronchospasm - however some patients may still need the betablocker

6
Q

what betablockers whould we chose if an asthma patient NEEDs a beta blocker

A
cardioselective ones
(e.g. bisoprolol, atenolol, metoprolol, nebivolol)
7
Q

why caution betablockers in diabetes

A

reduced warning of hypos (masks tachycardia)
may cause hypos/hypers by interfering in carb metabolism (in patients with or without diabetes)
-not entirely contraindicated
-even more caution if combined with thiazide like diuretic

8
Q

betablockers are good at reducing BP so why are other antihypertensives generally preferred for uncomplicated hypertension?

A

they are shown to be more effective in reducing incidence of stroke, MI and CV mortality

9
Q

in pheochromocytoma (adrenaline secreting tumour) what should be given with a betablocker to control pulse

A

phenoxybenzamine (alpha blocker)

jut blocking beta can lead to hypertensive crisis

10
Q

risks of abrupt withdrawl of betablockers (2)

A

rebound angina for pt with angina

worsening of ischaemia in IHD

11
Q

risks of using betablockers with verapamil

A

percipitation of HF

12
Q

what is the betablocker of choice in thyrotoxicosis

A

propranolol

13
Q

what skin condition are betablockers cautioned in

A

psoriasis - may trigger flare

14
Q

symptoms of beta blocker overdose

A
sycope
lightheadedness
dizziness
bradycardia
hypotension