Antiestrogens & antiprogestins Flashcards Preview

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Flashcards in Antiestrogens & antiprogestins Deck (17)
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1

Antiestrogens (2 groups)

Estrogen receptor antagonists
Aromatase inhibitors (estrogen synthesis inhibitors)

2

Estrogen receptor antagonists (6 drugs)

Clomiphene
Tamoxifen
Raloxifene
Toremifene
Ospemifene
Bazedoxifene

3

Clomiphene - indication

Anovulatory infertility (polycystic ovary disease)

4

Which estrogen receptor antagonist is used indicated for breast cancer?

Tamoxifen

5

Tamoxifen - MoA and adverse effects

Both estrogenic and antiestrogenic effects. Antagonist in breast --> inh breast cancer proliferation, agonist in endometrial tissue

Endometrial cancer
Vaginal bleeding
Hot flashes

6

Raloxifene - indications

Osteoporosis and reduces risk of breast cancer in postmenopausal women

7

Raloxifene - MOA

Estrogen-like effects on bone and lipid metabolism, antagonistic effect on breast and uterine tissue

8

Aromatase inhibitors (2 drugs)

Anastrozole
Letrozole

9

First-line treatment of locally advanced or metastatic breast cancer in postmenopausal women

Estrogen synthesis inhibitors (anastrozole & letrozole

10

Aromatase inhibitors - adverse effects

Hot flashes
Vaginal bleeding
Back pain

11

Antiprogestins (1 drug)

Mifepristone

12

Mifepristone - indications

Medical termination of pregnancy through 49 days gestation
Cushing's syndrome
Hyperglycemia

13

Mifepristone treatment is followed by

A prostaglandin (usually misopristol)

14

Mifepristone - adverse effects

Heavy uterine bleeding

15

Clomiphene - MoA and Adverse effects

Weak estrogen agonist and moderate estrogen antagonist. Increases FSH and LH, induce follicle maturation and ovulation

Multiple births and hot flashes

16

Toremifene - MoA, Clinical use and Adverse effect

Antagonist in breast tissue
Metastatic breast cancer in postmenopausal women
Hot flashes

17

Ospemifene - Clinical use

Dyspareunia (Pain during intercource)