Antiandrogens Flashcards Preview

34 Fertility and reproduction > Antiandrogens > Flashcards

Flashcards in Antiandrogens Deck (12)
Loading flashcards...
1

Antiandrogens (3 groups)

GnRH analogues
Androgen receptor antagonists
5α-reductase inhibitors

2

GnRH analogues (1 drug)

Leuprolide

3

Leuprolide - indications

Inoperable prostate cancer

4

Androgen receptor antagonists (5 drugs)

Flutamide
Bicalutamide
Enzalutamide
Nilutamide
Cyproterone

5

Difference between cyproterone and other androgen receptor antagonists

Cyproterone is a steroidal androgen receptor antagonist, while the others (flutamide, bicalutamide, nilutamide) er nonsteroidal

6

The nonsteroidal androgen antagonists - indications

Inoperable prostate cancer

7

Flutamide, bicalutamide, nilutamide - adverse effects

Impotence
Gynecomastia
Hepatitis

8

5α-reductase inhibitors (2 drugs)

Finasteride
Dutasteride

9

5α-reductase inhibitors - MOA

Blocks 5α-reductase, decreases DHT synthesis. Reduces prostate volume

10

5α-reductase inhibitors - indications

Symptomatic Benign Prostate Hyperplasia
Improve urinary flow and decrease risk of urinary retention

11

Finasteride - indications

Male pattern baldness

12

5α-reductase inhibitors - adverse effects

Aggressive cancer
Decreased libido
Erectile dysfunction
Gynecomastia