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Flashcards in Contraceptives Deck (18)
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1

Main groups of hormonal contraceptives (2 groups)

Estrogen-progestin contraceptives
Progestin-only contraceptive

2

Estrogen-progestin contraceptives - MOA

Synergistic suppression of ovulation, by feedback inhibition of GnRH secretion.
Estrogen component: decreased FSH secretion (no maturation of follicle).
Progestin component: inhibit LH surge (no ovulation).
Delayed maturation of endometrium, development of viscous cervical mucus

3

Estrogen-progestin contraceptives - indications

Contraceptives
Acne vulgaris
Dysmenorrhea

4

Estrogen-progestin contraceptives - cautions

Smoker over 35 y
Gall bladder disease

5

Estrogen-progestin contraceptives - contraindications

Thromboembolic disease
CAD
Active liver disease
Breast cancer
Carcinoma of reprod tract

6

Estrogen-progestin contraceptives - adverse effects

High BP, thromboembolic disorders, gallstones, effects of altered hormone levels

7

High doses of estrogen-progestin contraceptives increases the risk of

Breast cancer, stroke, MI, DVT

8

Which drugs may cause contraceptive failure

Carbamazepine & phenytoin.
Antibiotics (penicillins & tetracyclines)

9

Estrogen potentiate the effects of which drugs?

Cyclosporine
Antidepressants
Glucocorticoids

10

Types of estrogen-progestin contraceptives (2 groups)

Monophasic
Triphasic

11

Extended-cycle monophasic estrogen-progestin contraceptive and its indication

Ethinyl estradiol + levonorgestrel (sesonale).
Used for menstrual suppression

12

Triphasic estrogen-progestin contraceptive

Ethinyl estradiol + desogestrel (Natazia)

13

Transdermal skin patch - adverse effects

Greater incidence of venous throboembolism

14

Progestin-only contraceptives (3 drugs)

Norethinidrone (minipills)
Medroxyprogesterone acetate
Levonorgestrel

15

Progestin-only contraceptives - MOA

Decreases frequency of GnRH pulse and LH surge.
Thicken & decrease cervical mucus, create a thin, atrophic endometrium

16

Progestin-only contraceptives - adverse effects

Spotting
Amenorrhea
Ectopic pregnancy
Irregular mestruation

17

Emergency post-coital contraceptive (1 drug)

Levonorgestrel

18

Levonorgestrel is usually administered with ?

Promethazine