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34 Fertility and reproduction > Estrogens > Flashcards

Flashcards in Estrogens Deck (10)
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1

Estrogen preparations (6 drugs)

Conjugated equnie estrogens
Ethynyl estradiol
Mestranol
Micronized estradiol
Estradiol cypionate
Estradiol valerate

2

Estrogens - cautions and contraindications

Contraindications: pregnancy, uterine fibroids
Caution: hepatic disease, endometriosis, thromboembolic disease, hypercalcemia

3

Estrogens- adverse effects

Breast tenderness
Edema
Change in libido
Hypertension
Thromboembolic disorders
Gall bladder disease

4

Mestranol & ethinyl estradiol - indications

Oral estrogen-progestin contraceptives
Acne vulgaris
Dysmenorrhea

5

Estrogen used in heavy or prolonged menstrual bleeding

Estradiol valerate

6

Micronized and transdermal estradiol can be used for

Hormone replacement therapy in postmenopausal women

7

The contraceptive Natazia contains which estrogen?

Estradiol valerate

8

Administration of estradiol cypionate and valerate

IM (slow release)

9

Estrogens - MoA

Hypertensive effect: increases angiotensinogen synthesis
Thromboembolic effect: increased synthesis of clotting factors
Gallbladder disease: increased cholesterol excretion in bile
Decreases LDL, increases HDL
Epiphyseal closure
Prevents osteoporosis (inhibits bone resorption)
Bone and muscle growth
Endometrial growth
Female secondary characteristics
Sensitive myometrium to oxytocin
Protein synthesis in brain (mood)

10

Estrogens - Clinical use

Primary hypogonadism
Cases caused by surgical oophorectomy and menopause