Progesterones and derivatives

Question 1

Groups of progesterones (2 groups)

Answer 1

Progesterone esters

Synthetic progestins

Question 2

Progesterone esters - indications

Answer 2

Dysmenorrhea
Endometriosis
Uterine bleeding
HRT: comb with estrogen –> decrease estrogen induced irregular bleeding, prevent uterine hyperplasia and endometrial cancer

Question 3

Progesterone esters (3 drugs)

Answer 3

Megestrol
Hydroxyprogesterone caproate
Medroxyprogesterone acetate

Question 4

Which progesterone ester may reduce risk of preterm delivery?

Answer 4

Hydroxyprogesterone caproate

Question 5

Medroxyprogesterone acetate is found in which type of contraceptive?

Answer 5

Progestin-only contraceptive

Question 6

Synthetic progestins (5 drugs)

Answer 6

Norgestrel
Desogestrel
Norgestimate
Norethindrone
Drospirenone

Question 7

Synthetic progestins - indications

Answer 7

Oral contraceptives
Dysmenorrhea
Endometriosis
Uterine bleeding

Question 8

Most androgenic progestin

Answer 8

Norgestrel

Question 9

Antiandrogenic progestin

Answer 9

Drospirenone

Question 10

Progestins with low androgenic activity (2 drugs)

Answer 10

Desogestrel

Norgestimate

Question 11

Drospirenone - classification

Answer 11

Spironolactone derivative, aldosterone antagonist

Question 12

Norgestrel - adverse effects

Answer 12

Acne
Hirsutism
Increased libido
Oily skin

Question 13

Drospirenone - adverse effects

Answer 13

Low BT

Venous thromboembolism

Question 14

Progesterone - MoA

Answer 14

Stimulate lipoprotein lipase: fat deposition
Increases basal fat deposition
Promote glycogen storage
Preovulatory LH surge: maturation and changes in endometrium 
Increases body temp during ovulation
Mild mineralocorticoid
Increases LDL, decreases HDL
Triggers ovulation
Maintain pregnancy