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Flashcards in Progesterones and derivatives Deck (14)
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1

Groups of progesterones (2 groups)

Progesterone esters
Synthetic progestins

2

Progesterone esters - indications

Dysmenorrhea
Endometriosis
Uterine bleeding
HRT: comb with estrogen --> decrease estrogen induced irregular bleeding, prevent uterine hyperplasia and endometrial cancer

3

Progesterone esters (3 drugs)

Megestrol
Hydroxyprogesterone caproate
Medroxyprogesterone acetate

4

Which progesterone ester may reduce risk of preterm delivery?

Hydroxyprogesterone caproate

5

Medroxyprogesterone acetate is found in which type of contraceptive?

Progestin-only contraceptive

6

Synthetic progestins (5 drugs)

Norgestrel
Desogestrel
Norgestimate
Norethindrone
Drospirenone

7

Synthetic progestins - indications

Oral contraceptives
Dysmenorrhea
Endometriosis
Uterine bleeding

8

Most androgenic progestin

Norgestrel

9

Antiandrogenic progestin

Drospirenone

10

Progestins with low androgenic activity (2 drugs)

Desogestrel
Norgestimate

11

Drospirenone - classification

Spironolactone derivative, aldosterone antagonist

12

Norgestrel - adverse effects

Acne
Hirsutism
Increased libido
Oily skin

13

Drospirenone - adverse effects

Low BT
Venous thromboembolism

14

Progesterone - MoA

Stimulate lipoprotein lipase: fat deposition
Increases basal fat deposition
Promote glycogen storage
Preovulatory LH surge: maturation and changes in endometrium
Increases body temp during ovulation
Mild mineralocorticoid
Increases LDL, decreases HDL
Triggers ovulation
Maintain pregnancy