antifungal Flashcards
1
Q
what are the different types of fungal pathogens/infections?
A
- thrush
- oral thrush
- athletes foot
- toe nail infection
- dandruff
2
Q
what are the drug targets for antifungal tgherapy?
A
- cell membrane
- DNA synthesis
- cell wall
3
Q
what does fungals have in the cell wall that plays a key role?
A
-ergosterol
4
Q
what enzye can be inhibited to prvent ergosterol prodcution?
A
lanosterol 14a-demethylase
5
Q
what drug is used to inhibit lanosterol 14a-demethylase?
A
azoles
6
Q
what is the mode of action?
A
multi-step process most involving a cytochrme P450 enzyme co factor.
7
Q
where does azole bind to in teh cytochrome?
A
the iron in the enzyme
8
Q
why is monotherapy limited now for flucytosine in clinical uses?
A
because it can cause resistance
