Flashcards in antifungals Deck (71):
The amount of fungal infections has increased due to.....
What is the cause of resistance with Amp. B?
reduced Ergosterol (the target/binding site)
What is Amp. used intrathecal?
to treat fungal meningitis due to coccidoides
Are any of the -Azoles given with Amp B?
Which 3 drugs are HCV protease inhibitors and can added to Ribavirin?
Which one is a HCV RNA polymerase inhibitors that can be added to Ribavirin?
Which drug can be used ALONE for treatment of HCV?
Acylucovir is DOC for what 2?
Neonatal HSV infections
What are the 2 drugs in the HIV integrase strand inhibitors class?
What is the MOA for Amp B?
binds to ergosterol
Amp B is DOC for what?
most life threatening fungal infections
Amp B is 1st line for what 5?
1. Candida Albicans
2. Histoplasma capsulatum
3. Cryptococcus Neoformans (with flucytosine)
4. Coccidioides Immitits
What are 2 more indiciations for Amp B?
2. Blastomyces dermatidis
What is a reversible SE of Amp B?
What does Flucytosine treat?
1. Cryptococcal meningitis
What are the SE's of Flucytosine?
2. reversible bone marrow suppression
3. hepatic dysfunction
What is the MOA of Ketoconale?
What are the oral indiciations for letoconazole?
What are the topical indications for ketoconazole?
- cutaneous candidiasis
- seborrheic dermatitis
What role does Ketonazole play on steroids?
It decreases ALL steroid production
How is Ketonazole excreted from the body?
in the bile
What are the 4 SE;s of Ketonazole?
3. endocrine (gynecomastia, impotence, decreased libdo, menstrual irreglarities)
4. hepatic dysfunction
What are the drug interactions with ketconazole?
1. phenytoin and cyclosporine
2. warfarin, sucralfate, tolbutamide
What the MOA of Fluconazole?
prevents production of ergosterol
What are the first line treatments of fluconazole?
2. coccidioidomycosis (inc. meningitis)
3. cyrptococcal meningitis
Fluconazole is CI in who?
what drugs does fluconale interact with?
Itraconazole is first line for which ones?
4. AIDS- associated histoplasmosis
how is Itraconale excreted from the body?
In the bile
What are the SE's of Itraconazole?
N/V; skin rash; hypokalemia; HTN; edema; HA
What is Voriconazole first line for?
**also indicated for candida
What are the SE's of Voriconale?
- increased LFT's
- visual disturbances
- Abd pain
what is Posconazole first line for?
** also for salvage tx of invasive aspergillus
What is the ending of drugs in the Echinocandins class?
What is the MOA of the Echinocandins class?
inhibition of glucan synthase
What does the Echinocandins class treat?
- candida infections
What specifically does Micafungin treat?
prophy of candida in high-risk pts (bone marrow transplants)
what the MOA of Griseofulvin?
binds to the fungal microtubules
Griseofulvin is affective against ____ which includes which 3. and what other infection?
** severe tine infections
Griseofulvin is CI in who?
what is the MOA of Terbinafine and Naftin? tx of?
inhibit ergosterol biosynthesis; tinea infections
What does Nystatin tx?
Candida-- both oral and intestinal
What does Natamycin treat?
ophthlmic antifungal tx of candida, Fusarium, and Asperigillus
** keratitis, blepharitis, conjunctivitis
What do Tamiflu and Zanamivir treat?
influenza A and B
Tamilfu is PO; Zanamivir is inhalation (CI in asthma/COPD)
Both Tamiflu and Zanamivir are CI in who?
neonates and infants
what is the MOA of Ribavirin?
inhibition of viral transcription
Ribavirin treats what?
1. influenza A and B
2. HCV (CANNOT be given alone)
Ribavirin is CI in who?
what the MOA of Palivizumab?
inhibits RSV replication
prevents RSV in high risk peds
What is the MOA of acyclovir?
inhibits DNA polymerase and viral DNA synthesis
Acyclovir is 1st line for which 3?
Acyclovir also is prophy for what?
CMV in immunocompromised hosts
Valacyclovir is prodrug for what?
Valacyclovir is tx for what 3?
1. HSV1- herpes labialis
2. HSV2- genital herpes
what it the MOA of Trifluridine?tx?
inhibits DNA synthesis; topical HSV-1 keratitis and keratoconjuctivitis
What does Penciclovir treat?
HSV-1 herpes labialis
What does Famciclovir treat?
HSV1; HSV2; acute herpes zoster
What does Abreva treat?
topical OTC cream for herpes labilis
What 3 things does Ganciclovir tx?
1. CMV retinitis
2. acyclovir- resistant HSV
3. CMV prophy in transplant pts
Valganciclovir is a prodrug for what? tx?
Ganciclovir; CMV retinitis and CMV prophy
What does Cidofovir treat?
1. CMV retinits
2. HSV1 and HSV 2
What doesFoscarnet treat? and what is special about it?
only one that phosphorlation isn't needed
What does Zidovudine treat? 3 SE'?
1. bone marrow toxicitiy
2. HA/ sz
3.lactic acidosis, hepatomegaly, steatosis
What does Lamivudine treat?
2. Hep B
What are the common SE's of all NRTI's?
fatty enlargment of the liver and steatosis
What does Didanosine treat?
AZT resistant HIV
What does Stavudine treat?
What does Abacavir treat?
What is the suffix of allHIV protease inhibitors? When are the CI?
'Navir; with Rifampin
Nevirapine, Delavirdine, Efavirenz, and Etravirine are apart of which class?
NNRTI's for HIV
Bind to reerse transcriptase