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Flashcards in antifungals Deck (71):
1

The amount of fungal infections has increased due to.....

immunocompromised pts

2

What is the cause of resistance with Amp. B?

reduced Ergosterol (the target/binding site)

3

What is Amp. used intrathecal?

to treat fungal meningitis due to coccidoides

4

Are any of the -Azoles given with Amp B?

NO

5

Which 3 drugs are HCV protease inhibitors and can added to Ribavirin?

1. Boceprivir
2. Simeprevir
3. Telaprevir

6

Which one is a HCV RNA polymerase inhibitors that can be added to Ribavirin?

Sofobuvir

7

Which drug can be used ALONE for treatment of HCV?

Harvoni

8

Acylucovir is DOC for what 2?

HSV encephalitis

Neonatal HSV infections

9

What are the 2 drugs in the HIV integrase strand inhibitors class?

1. Raltegravir
2. Dolutegravir

10

What is the MOA for Amp B?

binds to ergosterol

11

Amp B is DOC for what?

most life threatening fungal infections

12

Amp B is 1st line for what 5?

1. Candida Albicans
2. Histoplasma capsulatum
3. Cryptococcus Neoformans (with flucytosine)
4. Coccidioides Immitits
5. Aspergillues

13

What are 2 more indiciations for Amp B?

1. Paracoccidiodes
2. Blastomyces dermatidis

14

What is a reversible SE of Amp B?

Renal impariment

15

What does Flucytosine treat?

1. Cryptococcal meningitis
2. Candida
3. Chromoblastomycosis

16

What are the SE's of Flucytosine?

1. GI
2. reversible bone marrow suppression
3. hepatic dysfunction

17

What is the MOA of Ketoconale?

inhibits ergosterol

18

What are the oral indiciations for letoconazole?

-canditiasis
- histoplasmosis
- 'mycosis
- blastomycosis

19

What are the topical indications for ketoconazole?

- tinea
- cutaneous candidiasis
- seborrheic dermatitis

20

What role does Ketonazole play on steroids?

It decreases ALL steroid production

21

How is Ketonazole excreted from the body?

in the bile

22

What are the 4 SE;s of Ketonazole?

1. GI
2. Allergies
3. endocrine (gynecomastia, impotence, decreased libdo, menstrual irreglarities)
4. hepatic dysfunction

23

What are the drug interactions with ketconazole?

1. phenytoin and cyclosporine
2. warfarin, sucralfate, tolbutamide
3. rifampin

24

What the MOA of Fluconazole?

prevents production of ergosterol

25

What are the first line treatments of fluconazole?

1. candida
2. coccidioidomycosis (inc. meningitis)
3. cyrptococcal meningitis

26

Fluconazole is CI in who?

Pregnancy

27

what drugs does fluconale interact with?

1. phenytoin
2. cyclosporine

28

Itraconazole is first line for which ones?

1. blastomycosis
2. paracoccidioidomycosis
3. histoplasmosis
4. AIDS- associated histoplasmosis

29

how is Itraconale excreted from the body?

In the bile

30

What are the SE's of Itraconazole?

N/V; skin rash; hypokalemia; HTN; edema; HA

31

What is Voriconazole first line for?

Aspergillosis

**also indicated for candida

32

What are the SE's of Voriconale?

- N/V/D
- rash
- increased LFT's
- visual disturbances
- Abd pain
- HA

33

what is Posconazole first line for?

prevention of:
1. Apergillus
2. Candida

** also for salvage tx of invasive aspergillus

34

What is the ending of drugs in the Echinocandins class?

' fungin

35

What is the MOA of the Echinocandins class?

inhibition of glucan synthase

36

What does the Echinocandins class treat?

- candida infections

37

What specifically does Micafungin treat?

prophy of candida in high-risk pts (bone marrow transplants)

38

what the MOA of Griseofulvin?

binds to the fungal microtubules

39

Griseofulvin is affective against ____ which includes which 3. and what other infection?

- dermatophytes

1. trichophyton
2. Microsporum
3. Epidermophyton

** severe tine infections

40

Griseofulvin is CI in who?

pregnancy

41

what is the MOA of Terbinafine and Naftin? tx of?

inhibit ergosterol biosynthesis; tinea infections

42

What does Nystatin tx?

Candida-- both oral and intestinal

43

What does Natamycin treat?

ophthlmic antifungal tx of candida, Fusarium, and Asperigillus


** keratitis, blepharitis, conjunctivitis

44

What do Tamiflu and Zanamivir treat?

influenza A and B

Tamilfu is PO; Zanamivir is inhalation (CI in asthma/COPD)

45

Both Tamiflu and Zanamivir are CI in who?

neonates and infants

46

what is the MOA of Ribavirin?

inhibition of viral transcription

47

Ribavirin treats what?

1. influenza A and B
2. HCV (CANNOT be given alone)

48

Ribavirin is CI in who?

pregnancy

49

what the MOA of Palivizumab?

inhibits RSV replication

prevents RSV in high risk peds

50

What is the MOA of acyclovir?

inhibits DNA polymerase and viral DNA synthesis

51

Acyclovir is 1st line for which 3?

1. HSV1
2. HSV2
3. varicella-zoster

52

Acyclovir also is prophy for what?

CMV in immunocompromised hosts

53

Valacyclovir is prodrug for what?

acyclovir

54

Valacyclovir is tx for what 3?

1. HSV1- herpes labialis
2. HSV2- genital herpes
3. varicella-zoster

55

what it the MOA of Trifluridine?tx?

inhibits DNA synthesis; topical HSV-1 keratitis and keratoconjuctivitis

56

What does Penciclovir treat?

HSV-1 herpes labialis

57

What does Famciclovir treat?

HSV1; HSV2; acute herpes zoster

58

What does Abreva treat?

topical OTC cream for herpes labilis

59

What 3 things does Ganciclovir tx?

1. CMV retinitis
2. acyclovir- resistant HSV
3. CMV prophy in transplant pts

60

Valganciclovir is a prodrug for what? tx?

Ganciclovir; CMV retinitis and CMV prophy

61

What does Cidofovir treat?

1. CMV retinits
2. HSV1 and HSV 2

62

What doesFoscarnet treat? and what is special about it?

CMV retinitis

only one that phosphorlation isn't needed

63

What does Zidovudine treat? 3 SE'?

HIV

1. bone marrow toxicitiy
2. HA/ sz
3.lactic acidosis, hepatomegaly, steatosis

64

What does Lamivudine treat?

1. HIV
2. Hep B

65

What are the common SE's of all NRTI's?

fatty enlargment of the liver and steatosis

66

What does Didanosine treat?

AZT resistant HIV

67

What does Stavudine treat?

advanced HIV

68

What does Abacavir treat?

advanced HIV

69

What is the suffix of allHIV protease inhibitors? When are the CI?

'Navir; with Rifampin

70

Nevirapine, Delavirdine, Efavirenz, and Etravirine are apart of which class?

NNRTI's for HIV

Bind to reerse transcriptase

71

Enfuvirtide and Maraviroc are in which class? SE?

HIV fusion inhibitors; E--> PNA; M--> Hepatitis