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Pharm test #1 > Macrolides > Flashcards

Flashcards in Macrolides Deck (22):
1

Erythromycin is first line for what 1?

1. Diphtheria ( Corynebacterium diphtheriae)

2

There are 2 method bacteria use to develope resistance to macrolides. Know which one goes with which gram stain?

Gram pos--> altered target site (50S) gram neg--> inactivation by esterase

3

T/F, if an organism is resistant to one macrolide, it's resistant to all of them?

True

4

Clarithromyacin is first line for ____ in combo with ethambutol? What ar 2 other things it is first line for?

MAI complex Chlamydia pneumoniae and corynebacterium diphtheria

5

Azithromycin has increased activity against what 2 gram - then other macrolides?

1. H. influenzae 2. Moraxella catarrhalis

6

What is the MOA of macrolides? They are ______

inhibit protein synthesis by binding to the 50S ribosome; bacteriostatic

7

What is characteristic of macrolides and ketolides?

macrocylic lactone ring

8

Clarithromycin: 1. how does it act in gastric aicd? 2. food? 3. excreted? 4. should the dose be decreased in a pt wth kidney failure?

1. increased stability 2. enhanced absoprtion 3. both the kidney and liver 4. YES

9

Describe azithromycin's 1/2 life?

It is VERYYYY long. So only 1 tab is needed to cure

10

What is the most widely used macrolide?

Azithromycin

11

SE of Telithromycin? CI in who?

Liver failure; those under 18, with liver disease, and with prolonged QT intervals

12

Azithromycin is first line for what 4?

1. Legionella 2. Chlamydia pneumo 3. Corynebacterium diphtheriae 4. Haemophilus ducreyi

13

Azithromycin: 1. food? 2. excreted?

1. decreases absorption 2. in the bile

14

Telithromycin is indicated for what? Which drig-resistant organism is it also indicated for?

treat of community acquired PNA; MDRSP (multi-drug resistant strep. pneumo)

15

Clarithromycin is also better for what 4 intracellular pathogens?

1. Chlamydia 2. legionella 3. mycobacterium avium intracellulare complex 4. ureaplasma

16

Clarithryomycin is similar to erythromycin, but better against ______

respiratory ( H. FLu)

17

Azithromycin is the DOC for what?

Chlamydia trachomatis

18

Erythromycin is alternative treatment for what 5 gram pos? ** for pts that are betalactam allergy

1. streptococcus pyogenes 2. Listeria monocytogenes (sepsis in newborns) 3. Bacillus anthracis (malignant pustule and PNA) 4. clostridium perfringens (gas gangrene and food poisoning) 5. clostridium tentani (tetanus)

19

Erythromycin: 1. Is inactivated by _______ and is excreted in the ______ 2. good to use if the pt is allergic to _____. 3. Does food enhance or decrease the absorption? 4. SE's?

1. Inactivated by gastric pH; Bile 2. PCN 3. decreases 4. GI upset, Ototoxicity, MI

20

What is the MOA of Telithromycin?

Bactericidal and inhibits protein synthesis of 50S. It binds to 2 seperate domains

21

Which 2 macrolides are okay in RF pts?

1. erythromycin 2. Azithromycin

22

Look at page 9

:)