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Flashcards in Sulfonamides Deck (26):
1

bactrim is used for what 2 things in men?

UTI/ Prostatitis

2

sulfomanides can cause _____ in pts with G6PDH def?

hemolytic anemia

3

Sulfomanides are CI in which group? Why?

new borns/infants, pregnant females increased risk for Kernicterus

4

What is polytrim used for?

bacterial conjunctivitis

5

Bactrim is used to treat gastroenteritis caused by what 2 bugs?

Salmonella and shigella

6

What is the role of Trimethoprim in bactrim/sulfatrim?

inhibit conversion of dihydrofolate to tetrahydrofolate

7

Sulfonamides are higly bound to albumin, they can displace other drugs like ______, leading to an increase in serum concentration of free blood

warfarin and methotrexate (increased bleeding)

8

sulfasalazine has anti-inflammatory uses beneficial for what 3?

1. ulcerative colitis 2. colitis 3. juvenule rheumatoid arthritis

9

bactrim is DOC for what 2 disease and their bugs?

1. Nocardia- pulmonary lesions 2. Pneumocystitis jiroveci- PNA

10

bactrim is first line for otitis, sinusitis, and PNA caused by what 2?

H. Flu and M. Catarrhalis

11

What is the indication of Sulfisoxazole acetyl and Erythromycin?

Otitis media in children (H. Flu)

12

What is the use of Mafenide?

topical for preventing burn infections

13

Does cross resistance exists among sulfonamides?

yes

14

What is the use for silver sulfadiazine?

topical to prevent burn infections

15

What is mechanism of action of Trimethoprim?

inhibitor of dihydrofolate reductase which reduces tetrahydrofolate

16

Is sulfasalazine absorbed in the GI tract?

no

17

What is the abx spectrum of sulfonamides?

many gram pos and gram neg

18

What is the indication of sulfamethoxazole and Trimethoprim (bactrim)?

synergistic abx actions

19

What are the 3 uses of Sulfacetamide?

topical for 1. ocular infections 2. acne 3. bacterial skin infections

20

Trimethoprim causes folate def, therefore leading to what 3 things? Can be treated with?

1. megaloblastic anemia 2. leukopenia 3. granulocytopenia Folinic acid

21

WHy must you drink lots of water when taking sulfonamides?

It can cause crystalluria and nephrotoxicity

22

Trimethoprim is good at treating what 2 things?

1. UTI 2. bacterial prostatitis

23

What is Kernicterus?

increased bilirubin in the CNS

24

What is the MOA of sulfonamides?

1. They inhibit the synthesis of bacterial folic acid 2. they compete with PABA for dihydropteroate synthetase, thereby inhibiting the incorporation of PABA into bacterial folic acid.

25

What is the indication of sulfadiazine and pyrimethamine?

Toxoplasmosis

26

PCN and sulfomamides can both cause what?

hypersensitivity reactions