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Flashcards in B-Lactam II Deck (52):
1

Cephamycins are a subclass of what group? They add coverage to what 4 bugs?

2nd gen ceph. 1. Bacteroides 2. Clostridium perfringens 3. N. Gonorrhoeae 4. Serratia

2

Can cephalosporins treat Listeria meningitides?

No

3

All cephalosporins are active against what gram neg rods? (3)

1. Proteus 2. E. Coli 3. Klebsiella

4

3rd gen ceph cover same as the 2nd gen plus what 4 gram neg rods?

1. Neisseria 2. Serratia 3. Citrobacter 4. Providencia

5

Primaxin is co/administered with what? why?

Cilastatin; inhibits the formation of a toxic metabolite

6

Cephalosporins are broader spectrum becuase they resist _______

B-lactamases

7

____ prolongs the activity of cephs by blocking tubular secretion?

Probenecid

8

Name the 2 Cephamycins?

1. Cefoxitin 2. Cefotetan

9

Which 2 are the DOC for neonatal and childhood meningitis caused by H. FLu?

1. Ceftriaxone 2. Cefotaxine

10

What is the broadest spectrum of the Carbapenems? used to treat?

Primaxin; UTI's and RTI's

11

Name the 3 first generation cephalosporins?

1. Keflex 2. Cefazolin 3. Cefadroxil

12

2nd gen ceph. also treat UTI's for what 2 bugs?

1. E.coli 2. Klebsiella

13

What is the MOA of Carbapenems?

inhibit cell wall synthesis

14

Cephalosporins are DOC for what 2 dz? bug?

1. PNA 2. UTI Klebsiella pneumoniae

15

What type of SE's for ceph have in the body?

hypersensitivity causing rash and anaphylactic shock

16

Cephalosporins are inactivated by ______

cephalsporease

17

How do Carbapenems structure look?

5 member ring the sulfa is outside of the A ring

18

Name the 6 most important 3rd gen ceph?

1. Ceftriaxone 2. Cefotaxime 3. Ceftazidime 4. Avycaz 5.Cefixime 6. Cefdinir

19

What is the only 3rd gen ceph that treats Bacteroid fragiles?

Ceftizoxime

20

Cefotetan is CI in which 2 pt types?

1. pts on blood thinners 2. cant be taken with alcohol (Disulfiram-like reactions)

21

Which 3rd gen ceph is used to treat intra-abd infections, complicated UTI's, and pyelonephritis?

Avycaz

22

1st gen are useful PCN bugs plus what other 3?

1. proteus mirabilis 2. E. Coli 3. Klebsiella pneumoniae

23

Which 3rd gen ceph is first line against pseudomonas Aeruginosa?

Ceftazidime

24

What type bug is Aztreonam active against?

Aerobic gram neg bacilli (Pseudomonas and Serratia)

25

Which ceph. is the drug of choice for surgical prophy?

Cefazolin

26

name 10 cephasporins that are given PO?

1. Cephalexin 2. Cefadroxil 3. Cefprozil 4. Cefuroxime axetil 5. Cefaclor 6. Cefdinir 7. Cefixime 8. Ceftibuten 9. cefpodoxime proxetil 10. cefditoren pivoxil

27

SE of Primaxin?

High doeses could cause sz.

28

Which Cephamycins is more active? Is the first line for what?

- Cefoxitin Peritonitis and diverticulitis (Bacteroides)

29

What is the best medication for Listeria meningitides?

Ampicillin

30

Are cephalosporins active against MRSA?

Only 5th generation Teflaro

31

Do Meropenem, Doripenem, and Ertapenem need to be admin with Cilastatin?

No.

32

Ceftriaxone is give ______ and first line for what 5 things

IV/IM 1. N. Gonorrhoeae 2. Meningitis due to H. flu 3. Chancroid due to H.Ducrey 4. PCN resistant Step. pneumo 5. typhoid fever from Salmonella

33

what is the only 5th gen ceph on the market?

- Teflaro

34

2nd gen have increased activity aginst what 2? Good for what dz?

1. H. influenzae 2. M. Catarrhalis Upper and lower respirtory infections

35

What is the most widely rx'd 3rd gen ceph? what is it used for?

- Cefdinir - CAP, bronchitis, sinusitis

36

Which PCN is excreted by the bile?

Naficilllin

37

4th gen ceph have increase resistance to ______

B-lactamases produced by Enterobacter **broadest!!!

38

All cephalosporins are active again what gram pos cocci?

1. staphylococci 2. sterptococci 3. pneumococci

39

which ceph is used during orthopedic surgery since it concentrates in the bone?

Cefazolin

40

5th gen has increased active against which 4?

1. MRSA 2. VRSA 3. VISA 4. Enterococcus Faecalis

41

Which cephalosporin is the msot widely rx'd?

Keflex

42

What is the structure like of the monobactam?

It has a B-lactam ring, but does not have an adjacent A-Ring. Therefore it is safe to use in pts with a PCN allergy

43

What is the most widely used 4th gen ceph? route?

Cefepime; IV

44

What is the mechanism of Cephalosporins?

They inhibit cell wall synthesis

45

Which ceph is excreted by the bile and is safe to sue in pts with renal failure?

Ceftriaxone

46

What is Aztreonam used to treat?

UTI's, PNA, and cystic fibrosis pts with respiratory symptoms

47

What are the 3rd generation cephalosporins used in treatment for?

1. gonorrhea 2. bacterial meningitis

48

4th gen ceph are first like for UTIs, PNA, bacteremia, and meningitis caused from ______ and for _____ infections

Pseudomonas aeruginosa; Intra abdominal

49

4 of the 3rd gen ceph that can cross the BBB and treat bacterial meningitis?

1. Ceftriaxone 2. Cefotaxime 3. Ceftazidime 4. Ceftizoxime

50

What is the only Monobactam on the market?

Aztreonam

51

name the 4 2nd gen ceph?

1. Cefprozil 2. Cefuroxime Axetil 3. Cefuroxime 4. Cefaclor

52

What is the formation of cephalosporins?

They have 6 atoms in adjacent ring