ANTIGEN TUMOR MARKERS

Question 1

marker of epithelial cells

Answer 1

keratin

Question 2

marker of carcinomas of lung, breasts, uterus, ovarian cancers

Answer 2

CK7 (+)

Question 3

colon and stomach cancers

Answer 3

CK20 (+)

Question 4

transitional cell carcinomas of bladder and mucinous ovarian tumors

Answer 4

CK7 and CK20 (+)

Question 5

renal cell carcinomas, liver carcinomas, prostatic adenocarcinomas, thyroid and squamous cell carcinomas

Answer 5

CK7 and CK20 neg

Question 6

helpful in determining the site of tumor; (+) for breast adenocarcinomas, lungs, and kidneys

Answer 6

EMA (Epithelial Membrane Antigen)

Question 7

an oncofetal antigen present carcinomas of GI tract, pancreas, lung, breast, ovary, uterus, cervix

Answer 7

CEA (Carcinoembryonic Antigen)

Question 8

DIFFERENTIATES adenocarcinoma (+) from mesothelioma (-)

Answer 8

CEA (Carcinoembryonic Antigen)

Question 9

DISTINGUISHES lung adenocarcinoma from mesothelioma

Answer 9

TTF-1 (Thyroid Transcription factor 1)

Question 10

present in thyroid gland neoplasms

Answer 10

TTF-1 (Thyroid Transcription Factor 1)

Question 11

(+) Prostate Adenocarcinoma, pancreatic, and salivary tumors

Answer 11

PSA (Prostatic Specific Antigen)

Question 12

normally found in breast epithelial cells but not myoepithelial cells

Answer 12

ER/PR (Estrogen/Progesterone Receptor)

Question 13

Prognosis and treatment of breast CA

Answer 13

ER/PR (Estrogen/Progesterone Receptor

Question 14

identification of metastatic breast CA

Answer 14

ER/PR (Estrogen/Progesterone Receptor)

Question 15

sensitive marker for muscle differentiation

Answer 15

actin

Question 16

identify tumors derived from smooth, skeletal, and cardiac muscles

Answer 16

actin

Question 17

normally present in mesenchymal cells and neoplastic cells such as sarcomas, lymphomas, leukemias, seminomas, neural tumors

Answer 17

vimentin

Question 18

always stain positive in vimentin

Answer 18

melanomas and schwannomas

Question 19

desmin is highly specific for

Answer 19

myogenic tumors

Question 20

normally expressed by CNS glial cells especially as

Answer 20

GFAP (glial fibrillary acidic protein)

Question 21

diagnosis of astrocytoma

Answer 21

GFAP (glial fibrillary acidic protein)

Question 22

expressed by cells of neural origin; (+) in neuroblastomas, ganglioneuromonas, neuromas, chemodectomas

Answer 22

neurofilament

Question 23

expressed by CNS glial cells, schwann cells, melanocytes, histiocytes, chrondrocytes, skeletal and cardiac muscles, myoepithelial cells, epithelial cells of the breast, salivary and sweat glands

Answer 23

S100 Protein (calcium binding protein)

Question 24

(+) for tumors with neural or neuroendocrine differentiation

Answer 24

NSE(Neuron specific enolase)

Question 25

found in neural secretory granules of endocrine tissues

Answer 25

chromogranin

Question 26

(+) neuroendocrine differentiation

Answer 26

chromogranin

Question 27

keratin (+), chromogranin (+)

Answer 27

neuroendocrine carcinomas

Question 28

present in presynaptic vesicles of neurons, normal neurons, and neuroendocrine cells

Answer 28

synaptophysin

Question 29

HCG is synthesized by placental ________

Answer 29

synctiotrophoblast

Question 30

(+) germ cell tumors/choriocarcinoma

Answer 30

HCG (Human Chorionic Gonadotropin)

Question 31

synthesized by normal liver; (+) hepatocellular CA

Answer 31

Alpha-fetoprotein (AFP)

Question 32

produced by placental syncytiotrophoblasts in late pregnancy

Answer 32

Placental-like Alkaline Antigen (PLAP)

Question 33

(+) germ cell tumors, embryonal CA, chorioCA, Endodermal sinus tumor, seminoma

Answer 33

Placental-like Alkaline Antigen (PLAP)

Question 34

tumors of skeletal muscle origin

Answer 34

myogenic tumors

Question 35

(+) Actin, Desmin, Myo D-1, Myoglobin, Myogenin

Answer 35

Myogenic tumors

Question 36

(+) CD68, FAM 56, Alpha-1 Antitrypsin, Alpha-1 Antichymotrypsin; Malignant Fibrohistiosarcoma

Answer 36

Fibrohistiocytic tumors

Question 37

(+) factor VII- related antigen, CD31, Ulex Europaeus (UEA); endothelial markers; angiosarcoma

Answer 37

vascular tumors

Question 38

(+) S100 protein

Answer 38

melanocytes are derived from the neural crest

Question 39

(+) HMB45

Answer 39

Melanosome

Question 40

(+) LCA (Leukocyte Common Antigen) aka CD45

Answer 40

Lymphoma

Question 41

best screening marker for lymphoma

Answer 41

Leukocyte Common Antigen (aka CD45)

Question 42

(+) CD15, CD30, Ig light and heavy chains

Answer 42

Reed-Sternberg

Question 43

used to assess proliferation of tumors

Answer 43

Ki-67 (MIB-1) and PCNA (Proliferating Cell Nuclear Antigen)

Question 44

(+) malignant tumors but not specific for malignancy

Answer 44

p53